Wang Chunyan, Mao Xia, Liu Songya, He Cheng, Wang Ying, Zhu Li, Wang Yangyang, Zhang Yicheng
Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clincal Trial and Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Case Rep Med. 2021 Jul 16;2021:9951122. doi: 10.1155/2021/9951122. eCollection 2021.
Angioimmunoblastic T cell lymphoma (AITL) is an aggressive Epstein-Barr virus-associated T cell lymphoma. Clinical syndromes of AITL are not confined to fever and lymphadenopathy, and patients may initially present with polyclonal plasma cell proliferation, which may obscure the underlying disease of AITL, delaying diagnosis. . Here, we report two AITL patients with excessive plasma cell proliferation in the bone marrow, peripheral blood, and ascites even mimicking plasma cell leukemia. Both of them had poor endings.
Our report emphasizes the complexity of the clinical manifestations of AITL, which aims to increase the alertness of physicians and improve the rate of early diagnosis. Integrated diagnostic approaches such as histopathology, flow cytometry, cytogenetics, and molecular biology are essential for accurate diagnosis and precise therapy.
血管免疫母细胞性T细胞淋巴瘤（AITL）是一种侵袭性的与爱泼斯坦-巴尔病毒相关的T细胞淋巴瘤。AITL的临床综合征并不局限于发热和淋巴结病，患者最初可能表现为多克隆浆细胞增殖，这可能掩盖AITL的潜在疾病，延迟诊断。在此，我们报告两例AITL患者，其骨髓、外周血和腹水中均有过度的浆细胞增殖，甚至酷似浆细胞白血病。他们两人结局都很差。
我们的报告强调了AITL临床表现的复杂性，旨在提高医生的警惕性并提高早期诊断率。组织病理学、流式细胞术、细胞遗传学和分子生物学等综合诊断方法对于准确诊断和精准治疗至关重要。
Zotero 插件