Mizutani T, Nomura H, Nakanishi K, Fujita S
Department of Food Science and Nutrition, Kyoto Prefectural University, Japan.
Res Commun Chem Pathol Pharmacol. 1987 Oct;58(1):75-83.
Intraperitoneal injection of R-(+)-pulegone (pulegone), the main constituent of pennyroyal oil, to ddY mice caused extensive liver injury as characterized by an increase in serum glutamic pyruvic transaminase (GPT) activity and centrilobular necrosis of hepatocytes. Treatments of mice with the cytochrome P-450 enzyme inhibitors, SKF-525A, metyrapone, piperonyl butoxide, and carbon disulfide (CS2), prevented or markedly alleviated the hepatotoxicity of pulegone. These results are compatible with the view that some metabolite of pulegone is responsible for the liver injury in mice.
向ddY小鼠腹腔注射薄荷油的主要成分R-(+)-长叶薄荷酮（长叶薄荷酮），会导致广泛的肝损伤，其特征是血清谷丙转氨酶（GPT）活性增加以及肝细胞的小叶中心坏死。用细胞色素P-450酶抑制剂SKF-525A、甲吡酮、胡椒基丁醚和二硫化碳（CS2）处理小鼠，可预防或显著减轻长叶薄荷酮的肝毒性。这些结果与长叶薄荷酮的某些代谢产物导致小鼠肝损伤的观点一致。
