人类肾类器官在肾脏疾病建模中的应用。
The Utility of Human Kidney Organoids in Modeling Kidney Disease.
机构信息
Department of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
Department of Developmental Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
出版信息
Semin Nephrol. 2020 Mar;40(2):188-198. doi: 10.1016/j.semnephrol.2020.01.009.
Abstract
The formation of three-dimensional kidney tissue (organoids) from human pluripotent stem cell lines provides a valuable tool to examine kidney function in an in vitro model and could be used for regenerative medicine approaches. Kidney organoids have the potential to model kidney diseases and congenital defects, be used for drug development, and to further our understanding of acute kidney injury, fibrosis, and chronic kidney disease. In this review, we examine the current stage of pluripotent stem cell-derived kidney organoid technology, challenges, shortcomings, and regenerative potential of kidney organoids in the future.
摘要
从人类多能干细胞系中形成三维肾组织（类器官）为在体外模型中检查肾脏功能提供了有价值的工具，并可用于再生医学方法。肾类器官有可能模拟肾脏疾病和先天性缺陷，可用于药物开发，并有助于进一步了解急性肾损伤、纤维化和慢性肾病。在这篇综述中，我们检查了多能干细胞衍生的肾类器官技术的当前阶段、挑战、缺点以及肾类器官在未来的再生潜力。
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