Department of Pharmacy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Surgical Intensive Care Unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Ann Palliat Med. 2021 Aug;10(8):8651-8664. doi: 10.21037/apm-21-981. Epub 2021 Jul 30.
Drug-induced liver injury (DILI) has become one of the most common and serious adverse drug reactions owing to its high morbidity and leading cause of hepatic failures, which had attracted great attentions worldwide in the past two decades. A need therefore exists to conduct a bibliometric and visualized analysis of the global research trends on DILI with the aim of identifying the status of current research and prioritize the future research areas.
Publications related to DILI from 1999 to 2019 were extracted through an electronic search of the Web of Science (WoS) and PubMed databases. VOSviewer software was used to perform visualized analysis of bibliographic coupling, co-authorship, co-citation and co-occurrence, and to assess the global trends.
Totally of 6,563 publications were identified based on the inclusion criteria. It is noted that the global trends of literatures on DILI showed a significant increase over time and more importantly predict the relevant publications will rise continuously in the coming decades. The United States led in terms of publication numbers with the most citations (the highest H-index). Hepatology made great contributions to the highest H-index and the most citations of publications. University of North Carolina was regarded as the most contributive institution. Notably, after conducting co-occurrence and cluster analysis of keywords and citation networks, it is shown that the pathogenesis, clinical manifestations, diagnosis and risk factors of this field will become the most prominent research hotspots.
The mapping results provides global development trends of publications on DILI from 1999 to 2019. Future studies focused on the diagnosis and predisposing factors of this field will be encouraged.
药物性肝损伤（DILI）由于其高发病率和导致肝衰竭的主要原因，已成为最常见和最严重的药物不良反应之一，在过去二十年中引起了全球的极大关注。因此，有必要对 DILI 的全球研究趋势进行文献计量和可视化分析，以确定当前研究的现状，并确定未来的研究重点。
通过对 Web of Science（WoS）和 PubMed 数据库的电子检索，提取了 1999 年至 2019 年与 DILI 相关的出版物。使用 VOSviewer 软件对文献耦合、合著、共引和共现进行可视化分析，并评估全球趋势。
根据纳入标准，共确定了 6563 篇出版物。值得注意的是，DILI 文献的全球趋势随着时间的推移呈显著增长，更重要的是，预测相关出版物在未来几十年将继续不断增加。美国在出版物数量上处于领先地位，引文数量（最高 H 指数）最多。肝脏病学对出版物的最高 H 指数和最高引文数做出了巨大贡献。北卡罗来纳大学被认为是最有贡献的机构。值得注意的是，对关键词和引文网络进行共现和聚类分析后，表明该领域的发病机制、临床表现、诊断和危险因素将成为最突出的研究热点。
该映射结果提供了 1999 年至 2019 年 DILI 出版物的全球发展趋势。鼓励未来的研究集中在该领域的诊断和易患因素上。
