Opt Lett. 2021 Aug 1;46(15):3801-3804. doi: 10.1364/OL.430044.
A method to realize surface-enhanced Raman spectroscopy (SERS) at a titanium alloy substrate for glucose detection has been experimentally demonstrated. A silver-coated laser-induced periodic surface structure (LIPSS) was prepared via femtosecond laser micro-processing. The low detection limit of glucose is 10/ and, a good linear relationship between the glucose concentration and Raman intensity is found in the range between 1×10 and 1×10/. Moreover, we investigate SERS detection for glucose sensing in human urine samples, while the results are in good agreement with clinical results. The Letter provides a facile method for producing a structure-controlled SERS substrate to realize glucose detection, which is promising for long-term in vivo diagnostics.
一种在钛合金基底上实现表面增强拉曼光谱（SERS）用于葡萄糖检测的方法已被实验证明。通过飞秒激光微加工制备了银覆盖的激光诱导周期表面结构（LIPSS）。葡萄糖的低检测限为 10 摩尔，在 1×10 到 1×10 摩尔范围内发现葡萄糖浓度与拉曼强度之间存在良好的线性关系。此外，我们研究了人尿液样本中葡萄糖的 SERS 检测，结果与临床结果吻合良好。该快报提供了一种生产结构可控 SERS 基底以实现葡萄糖检测的简易方法，有望用于长期的体内诊断。
