Xu Ziyi, Wang Yanxiao Austin, Ng Vivian, Yin Hongyan, Xu Shuai
Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117583, Singapore.
Department of Electrical and Computer Engineering, College of Design and Engineering, National University of Singapore, Singapore 117576, Singapore.
Nanomaterials (Basel). 2025 Jun 27;15(13):999. doi: 10.3390/nano15130999.
Functional and safety requirements for medical devices are increasing with the continuous advancement of medical technology. To improve the therapeutic effect and safety of medical devices and patients, researchers are constantly exploring new materials and processes. Among them, the preparation of functional surfaces has become an important means to improve the performance of medical devices. This paper provides a comprehensive and critical review of recent advancements in laser processing technologies for the fabrication of functional surfaces in medical devices. Leveraging the unique capabilities of laser-based techniques to precisely tailor micro- and nanoscale surface structures, these methods have demonstrated remarkable potential in enhancing the therapeutic efficacy, biocompatibility, and overall safety of medical implants and surgical instruments. Such innovations are paving the way for the development of next-generation medical devices with multifunctional surface properties, meeting the increasing demands of modern clinical applications. The review focuses on the key applications, including cell function regulation, antibacterial properties, corrosion resistance, friction characteristics, and anti-adhesion properties. It also explores the considerable potential of laser processing technology, while addressing the challenges associated with multifunctional surface design and material selection. Looking ahead, the paper discusses future directions for the application of laser processing in novel materials and complex biomimetic structures.
随着医疗技术的不断进步，对医疗设备的功能和安全要求也在提高。为了提高医疗设备的治疗效果和安全性以及患者的安全性，研究人员不断探索新材料和新工艺。其中，功能性表面的制备已成为提高医疗设备性能的重要手段。本文对用于制造医疗设备功能性表面的激光加工技术的最新进展进行了全面而批判性的综述。利用基于激光的技术精确调整微米和纳米级表面结构的独特能力，这些方法在提高医疗植入物和手术器械的治疗效果、生物相容性和整体安全性方面已显示出巨大潜力。此类创新为具有多功能表面特性的下一代医疗设备的开发铺平了道路，满足了现代临床应用日益增长的需求。该综述重点关注关键应用，包括细胞功能调节、抗菌性能、耐腐蚀性、摩擦特性和抗粘附性能。它还探讨了激光加工技术的巨大潜力，同时解决了与多功能表面设计和材料选择相关的挑战。展望未来，本文讨论了激光加工在新型材料和复杂仿生结构中的应用的未来方向。
