Department of Anesthesia, Multidisciplinary Pain Center, Pain and Respiratory Support, Neuroscience Center, Copenhagen University Hospital, Copenhagen, Denmark.
Department of Physiology, University of Kentucky, Lexington, KY, United States of America.
PLoS One. 2021 Jul 30;16(7):e0254790. doi: 10.1371/journal.pone.0254790. eCollection 2021.
The contact burn injury model is an experimental contact thermode-based physiological pain model primarily applied in research of drug efficacy in humans. The employment of the contact burn injury model across studies has been inconsistent regarding essential methodological variables, challenging the validity of the model. This systematic review analyzes methodologies, outcomes, and research applications of the contact burn injury model. Based on these results, we propose an improved contact burn injury testing paradigm. A literature search was conducted (15-JUL-2020) using PubMed, EMBASE, Web of Science, and Google Scholar. Sixty-four studies were included. The contact burn injury model induced consistent levels of primary and secondary hyperalgesia. However, the analyses revealed variations in the methodology of the contact burn injury heating paradigm and the post-burn application of test stimuli. The contact burn injury model had limited testing sensitivity in demonstrating analgesic efficacy. There was a weak correlation between experimental and clinical pain intensity variables. The data analysis was limited by the methodological heterogenicity of the different studies and a high risk of bias across the studies. In conclusion, although the contact burn injury model provides robust hyperalgesia, it has limited efficacy in testing analgesic drug response. Recommendations for future use of the model are being provided, but further research is needed to improve the sensitivity of the contact burn injury method. The protocol for this review has been published in PROSPERO (ID: CRD42019133734).
接触性烧伤损伤模型是一种基于接触式热电极的实验性生理疼痛模型，主要应用于人体药物疗效的研究。接触性烧伤损伤模型在不同研究中的应用存在不一致性，这对模型的有效性提出了挑战。本系统评价分析了接触性烧伤损伤模型的方法学、结果和研究应用。基于这些结果，我们提出了一种改进的接触性烧伤损伤测试范例。使用 PubMed、EMBASE、Web of Science 和 Google Scholar 进行了文献检索（2020 年 7 月 15 日）。共纳入 64 项研究。接触性烧伤损伤模型可引起一致的原发性和继发性痛觉过敏。然而，分析显示接触性烧伤加热范例和烧伤后测试刺激应用的方法学存在差异。接触性烧伤损伤模型在展示镇痛疗效方面的测试敏感性有限。实验性和临床疼痛强度变量之间的相关性较弱。数据分析受到不同研究方法学异质性和研究中偏倚风险高的限制。总之，尽管接触性烧伤损伤模型提供了可靠的痛觉过敏，但在测试镇痛药物反应方面的疗效有限。本研究为模型的未来应用提供了建议，但需要进一步研究以提高接触性烧伤方法的敏感性。本综述的方案已在 PROSPERO（注册号：CRD42019133734）上发表。
