Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Am J Hypertens. 2021 Dec 1;34(12):1276-1283. doi: 10.1093/ajh/hpab122.
Low baroreflex sensitivity (BRS) was an established risk factor for cardiovascular disorders. We investigated determinants of BRS in a large sample from general population.
In a population-based study (n = 901), data were collected on BRS, arm cuff blood pressure (BP), and obesity indices including body mass index, waist-to-hip ratio, waist circumference, and percentage body fat (%BF). BRS was calculated by spectral analysis software based on continuously recorded spontaneous fluctuations in beat-to-beat finger BP for 10-15 minutes. Correlations and multivariable regression analyses were used to test associations of age, sex, obesity indices, and hypertension with BRS while considering effects of lifestyle factors (smoking, alcohol consumption, and physical activity).
In multivariable analysis, age, sex, %BF, and hypertension were independently associated with BRS. BRS decreased with -0.10 (95% confidence interval: -0.15 to -0.06) ms/mm Hg with each year of increase in age. Women had -1.55 (95% confidence interval: -2.28 to -0.73) ms/mm Hg lower mean BRS than men. The effects of %BF (per 10% increase) and hypertension on BRS were -0.55 (95% confidence interval: -0.97 to -0.13) ms/mm Hg and -1.23 (95% confidence interval: -1.92 to -0.46) ms/mm Hg, respectively. There was no evidence of associations between BRS and lifestyle factors. Age, age2, sex, and their interactions plus %BF and hypertension contributed 16.9% of total variance of BRS.
In this large general population study, we confirmed prior findings that age and sex were important factors associated with BRS and found %BF was more strongly related to less favorable BRS levels than body mass index.
低反射血压敏感性（BRS）是心血管疾病的既定危险因素。我们在一个来自普通人群的大样本中研究了 BRS 的决定因素。
在一项基于人群的研究（n=901）中，收集了 BRS、手臂袖带血压（BP）和肥胖指数的数据，包括体重指数、腰臀比、腰围和体脂百分比（%BF）。BRS 通过基于连续记录 10-15 分钟指尖 BP 自发性波动的频谱分析软件计算得出。使用相关和多元回归分析来测试年龄、性别、肥胖指数和高血压与 BRS 的关联，同时考虑生活方式因素（吸烟、饮酒和体力活动）的影响。
多元分析中，年龄、性别、%BF 和高血压与 BRS 独立相关。BRS 随年龄每增加 1 岁而下降 0.10（95%置信区间：-0.15 至 -0.06）ms/mm Hg。女性的平均 BRS 比男性低 1.55（95%置信区间：-2.28 至 -0.73）ms/mm Hg。%BF（每增加 10%）和高血压对 BRS 的影响分别为-0.55（95%置信区间：-0.97 至 -0.13）ms/mm Hg 和-1.23（95%置信区间：-1.92 至 -0.46）ms/mm Hg。BRS 与生活方式因素之间没有关联的证据。年龄、年龄 2、性别及其相互作用加上%BF 和高血压对 BRS 总方差的贡献为 16.9%。
在这项大型普通人群研究中，我们证实了先前的发现，即年龄和性别是与 BRS 相关的重要因素，并且发现%BF 与较低的 BRS 水平的相关性强于体重指数。
