College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China; School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, PR China.
College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China.
Acta Biomater. 2021 Oct 15;134:664-673. doi: 10.1016/j.actbio.2021.07.050. Epub 2021 Jul 27.
Controllable and on-demand delivery of agrochemicals such as plant hormones is conducive to improving agrochemicals utilization, tackling water and environmental pollution, reducing soil acidification, and realizing the goals of precision agriculture. Herein, a smart plant hormone delivery system based on metal-organic frameworks (MOFs) and supramolecular nanovalves, namely gibberellin (GA)-loaded CLT6@PCN-Q, is constructed through supramolecular host-guest interaction to regulate the growth of dicotyledonous Chinese cabbage and monocotyledonous wheat. The porous nanoscale MOF (NMOF) with a uniform diameter of 97 nm modified by quaternary ammonium (Q) stalks is served as a cargo reservoir, followed by the decoration of carboxylated leaning tower[6]arene (CLT6) based nanovalves on NMOF surfaces through host-guest interactions to fabricate CLT6@PCN-Q with a diameter of ∼101 nm and a zeta potential value of -13.2 mV. Interestingly, the as-fabricated supramolecular nanoplatform exhibits efficient cargo loading and multi-stimuli-responsive release under various external stimuli including pH, temperature, and competitive agent spermine (SPM), which can realize the on-demand release of cargo. In addition, GA-loaded CLT6@PCN-Q is capable of effectively promoting the seeds germination of wheat and stem growth of dicotyledonous Chinese cabbage and monocotyledonous wheat (1.86 and 1.30 times of control groups, respectively). The smart supramolecular nanoplatform based on MOFs and supramolecular nanovalves paves a way for the controlled delivery of plant hormones and other agrochemicals for promoting plant growth, offering new insights and methods to realize precision agriculture. STATEMENT OF SIGNIFICANCE: To achieve controllable and sustainable release of cargos such as agrochemicals, a smart MOF-based multi-stimuli-responsive supramolecular nanoplatform equipped with supramolecular nanovalves was fabricated via the host-guest interaction between quaternary ammonium stalks-functionalized nanoMOFs and water-soluble leaning tower[6]arene. The as-prepared supramolecular nanoplatform with uniform diameter distribution demonstrated good cargo release in response to various external stimuli. The installation of synthetic macrocycles could effectively reduce cargo loss in the pre-treatment process. This type of supramolecular nanoplatform exhibited good promoting effect on seed germination and plant growth dicotyledonous Chinese cabbage and monocotyledonous wheat. As an eco-friendly, controlled, and efficient cargo delivery system, this supramolecular nanoplatform will be a promising candidate in precision agriculture and controlled drug release to attract the broad readership.
可控且按需递送农用化学品（如植物激素）有利于提高农用化学品的利用率，解决水污染和环境污染问题，减少土壤酸化，实现精准农业的目标。在此，通过超分子主客体相互作用构建了一种基于金属有机框架（MOFs）和超分子纳米阀的智能植物激素递送系统，即负载赤霉素（GA）的 CLT6@PCN-Q，以调节双子叶白菜和单子叶小麦的生长。用季铵（Q）茎修饰的多孔纳米级 MOF（NMOF）作为货物库，然后通过主客体相互作用在 NMOF 表面上装饰基于羧基斜方[6]芳烃（CLT6）的纳米阀，以制造直径约为 101nm、Zeta 电位值为-13.2mV 的 CLT6@PCN-Q。有趣的是，所制备的超分子纳米平台在各种外部刺激（包括 pH 值、温度和竞争性试剂精胺（SPM））下表现出高效的货物负载和多刺激响应释放，可实现货物的按需释放。此外，负载 GA 的 CLT6@PCN-Q 能够有效促进小麦种子发芽和双子叶白菜和单子叶小麦的茎生长（分别为对照组的 1.86 和 1.30 倍）。基于 MOFs 和超分子纳米阀的智能超分子纳米平台为农用化学品等货物的可控输送铺平了道路，为促进植物生长提供了新的见解和方法，实现了精准农业。
为了实现农用化学品等货物的可控和可持续释放，通过季铵盐功能化纳米 MOFs 和水溶性斜方[6]芳烃之间的主客体相互作用，制备了一种智能 MOF 基多刺激响应超分子纳米平台，该平台配备了超分子纳米阀。具有均匀粒径分布的制备超分子纳米平台在响应各种外部刺激时表现出良好的货物释放性能。合成大环的安装可以有效减少预处理过程中的货物损失。这种超分子纳米平台对双子叶白菜和单子叶小麦的种子发芽和植物生长表现出良好的促进作用。作为一种环保、可控、高效的货物输送系统，这种超分子纳米平台在精准农业和控制药物释放方面具有广阔的应用前景，将吸引广大读者的关注。
