Department of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510250, China.
Department of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510250, China.
Diabetes Res Clin Pract. 2021 Aug;178:108989. doi: 10.1016/j.diabres.2021.108989. Epub 2021 Jul 28.
Flash continuous glucose monitoring system (FCGM) reports nocturnal hypoglycemia with low accuracy in low blood glucose. In our study, we aimed to evaluate the accuracy and clinic profile of FCGM data out of range in T2DM.
FCGM data out of range were measured in T2DM patients at eight-time points of a day and compared with fingertip capillary blood glucose levels (REFs) as reference values.
A total of 307 out-of-range cases from 25,886 paired FCGM/REF data from 742 T2DM patients were evaluated. The distribution of "LO" and "HI" cases displayed the significant difference between eight-time points (P < 0.001) with the highest frequency (6.52%) of the "LO" value at 3 AM. The consistency rate between FCGM "LO" readings and REF < 40 mg/dl was far lower than that of FCGM "HI" readings with REF > 500 mg/dl (0.84% vs. 52.2%). In addition, the frequency of some clinical characteristics, including diabetes duration, hypoglycemia, hypertension, HbA1c, and Hb, were higher in patients with FCGM "LO" readings compared to those with "HI" readings.
These findings suggest the results and treatment regarding FCGM "LO" data should be interpreted with strong caution in the light of the emerging possible adverse measurement in patients.
在低血糖情况下，瞬态血糖监测系统（FCGM）报告夜间低血糖的准确性较低。在本研究中，我们旨在评估 T2DM 患者 FCGM 数据超出范围的准确性和临床特征。
在 742 例 T2DM 患者的一天 8 个时间点测量 FCGM 数据超出范围，并将其与指尖毛细血管血糖水平（REFs）作为参考值进行比较。
从 742 例 T2DM 患者的 25886 对 FCGM/REF 数据中评估了 307 例超出范围的病例。“低值（LO）”和“高值（HI）”病例的分布在 8 个时间点之间存在显著差异（P<0.001），其中凌晨 3 点的“LO”值出现频率最高（6.52%）。FCGM“LO”读数与 REF<40mg/dl 的一致性率远低于 FCGM“HI”读数与 REF>500mg/dl 的一致性率（0.84% vs. 52.2%）。此外，与 FCGM“HI”读数相比，FCGM“LO”读数患者的糖尿病病程、低血糖、高血压、HbA1c 和 Hb 等某些临床特征的频率更高。
这些发现表明，鉴于患者可能出现的不良测量结果，对于 FCGM“LO”数据的结果和治疗，应谨慎解读。
