Burdock Group Consultants, Orlando, FL, 32814, USA.
Burdock Group Consultants, Orlando, FL, 32814, USA.
Food Chem Toxicol. 2021 Oct;156:112444. doi: 10.1016/j.fct.2021.112444. Epub 2021 Jul 28.
In the food industry, most fatty acid-rich oils are primarily composed of saturated even-chain fatty acids. However, saturated odd-chain fatty acids are potentially a beneficial alternative to other saturated fatty acid-containing oils. In this communication, we examine the safety of odd-chain fatty acid (OCFA) algal oil, a microalgal-sourced oil composed primarily of the saturated odd-chain fatty acids pentadecanoic acid and heptadecanoic acid. OCFA algal oil was assessed for toxicity in a 14-day palatability study and comprehensive 13-week dietary study at inclusion levels of 5%, 10%, and 15% in the diet, utilizing a DHA-rich algal oil as a comparator control. No adverse effects attributed to the consumption of OCFA algal oil were observed in either study. Therefore, we report a No Observable Adverse Effect Level (NOAEL) of 150,000 ppm (15% in the diet), equivalent to an OCFA algal oil intake of 7553.9 and 8387.7 mg/kg bw/day for male and female rats, respectively. The genotoxic potential of OCFA algal oil was also examined in an in vitro bacterial reverse mutation assay and in vivo mammalian bone marrow chromosome aberration test. OCFA algal oil was non-mutagenic in Salmonella typhimurium and Escherichia coli test strains and did not exhibit clastogenicity in vivo.
在食品工业中，大多数富含脂肪酸的油主要由饱和偶数链脂肪酸组成。然而，饱和奇数链脂肪酸可能是其他含饱和脂肪酸油的有益替代品。在本通讯中，我们研究了奇数链脂肪酸（OCFA）藻油的安全性，OCFA 藻油是一种源自微藻的油，主要由饱和奇数链脂肪酸十五烷酸和十七烷酸组成。OCFA 藻油在为期 14 天的适口性研究和为期 13 周的全面饮食研究中进行了毒性评估，在饮食中以富含 DHA 的藻油作为比较对照，添加水平分别为 5%、10%和 15%。在这两项研究中，均未观察到与食用 OCFA 藻油相关的不良反应。因此，我们报告的无可见不良效应水平（NOAEL）为 150000ppm（饮食中的 15%），相当于雄性和雌性大鼠分别摄入 7553.9 和 8387.7mg/kg bw/day 的 OCFA 藻油。OCFA 藻油的遗传毒性潜力也在体外细菌回复突变试验和体内哺乳动物骨髓染色体畸变试验中进行了研究。OCFA 藻油在鼠伤寒沙门氏菌和大肠杆菌测试菌株中无致突变性，在体内也没有表现出染色体断裂作用。
