University of Science and Technology of China, Hefei, 230026, People's Republic of China; CAS Key Laboratory of Biomedical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science (CAS), 88 Keling Road, Suzhou, 215163, People's Republic of China.
CAS Key Laboratory of Biomedical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science (CAS), 88 Keling Road, Suzhou, 215163, People's Republic of China.
Environ Toxicol Pharmacol. 2021 Oct;87:103720. doi: 10.1016/j.etap.2021.103720. Epub 2021 Jul 28.
Silica nanoparticles (SiNPs) and cadmium chloride (CdCl) are two important environmental pollutants. In previous research, found that SiNPs in zebrafish larvae can amplify the cardiovascular damage caused by cadmium. Whether SiNPs in the ovaries can amplify the adverse effects of cadmium on the zebrafish ovaries is worth studying problem. In this study, sexually mature female zebrafish were used as model organisms and exposed to 1 μmol/L CdCl and/or 25 μg/mL SiNPs for 30 days. The results showed that the structure and function of ovaries in the sole and combined exposure groups changed significantly, resulting in reduced ovarian quality, decreased number of mature oocytes, and the development of malformed offspring. A deep-sequencing analysis showed that organisms' lipid metabolism and transportation, estrogen metabolism, and response to the maturation, meiosis, and vitellogenin synthesis of oocytes were significantly affected by single exposure or combined exposure. These findings provide further insights into the harm of cooperation of CdCl2 and/or SiNPs to the aquatic ecosystems.
硅纳米颗粒 (SiNPs) 和氯化镉 (CdCl) 是两种重要的环境污染物。在之前的研究中，发现 SiNPs 可在斑马鱼幼虫体内放大镉引起的心血管损伤。SiNPs 是否可在卵巢中放大镉对斑马鱼卵巢的不良影响，是一个值得研究的问题。在这项研究中，使用性成熟的雌性斑马鱼作为模型生物，并将其暴露于 1μmol/L CdCl 和/或 25μg/mL SiNPs 中 30 天。结果表明，单一和联合暴露组的卵巢结构和功能发生明显变化，导致卵巢质量降低、成熟卵母细胞数量减少以及畸形后代的发育。深度测序分析表明，单一或联合暴露显著影响生物的脂质代谢和运输、雌激素代谢以及卵母细胞的成熟、减数分裂和卵黄蛋白原合成的反应。这些发现为 CdCl2 和/或 SiNPs 对水生生态系统的协同危害提供了进一步的认识。
