Liu Yinai, Chen Qianqian, Li Yaoqi, Bi Liuliu, Jin Libo, Peng Renyi
Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang Province, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Toxics. 2022 Oct 19;10(10):622. doi: 10.3390/toxics10100622.
Large amounts of enriched cadmium (Cd) in the environment seriously threatens the healthy and sustainable development of the aquaculture industry and greatly restricts the development of the food processing industry. Studying the distribution and toxic effects of Cd in fish, as well as the possible toxic effects of Cd on the human body, is very significant. A large number of studies have shown that the accumulation and distribution of Cd in fish are biologically specific, cause tissue differences, and seriously damage the integrity of tissue structure and function, the antioxidant defense system, the reproductive regulation system, and the immune system. The physiological, biochemical, enzyme, molecular, and gene expression levels change with different concentrations and times of Cd exposure, and these changes are closely related to the target sites of Cd action and tissues in fish. Therefore, the toxic effects of Cd on fish occur with multiple tissues, systems, and levels.
环境中大量富集的镉（Cd）严重威胁着水产养殖业的健康可持续发展，并极大地限制了食品加工业的发展。研究镉在鱼类中的分布和毒性效应，以及镉对人体可能产生的毒性作用，具有十分重要的意义。大量研究表明，镉在鱼类中的积累和分布具有生物学特异性，会导致组织差异，并严重损害组织结构和功能的完整性、抗氧化防御系统、生殖调节系统和免疫系统。生理、生化、酶、分子和基因表达水平会随着镉暴露浓度和时间的不同而发生变化，这些变化与镉在鱼类中的作用靶点和组织密切相关。因此，镉对鱼类的毒性作用发生在多个组织、系统和水平上。
