Below Samantha, Williams Elizabeth
Medical College of Wisconsin Affiliated Hospitals, 8701 W Watertown Plank Rd, WI, 53226, Wauwatosa, USA.
Thromb J. 2021 Jul 31;19(1):52. doi: 10.1186/s12959-021-00306-6.
Lemierre's syndrome is a rare oropharyngeal infection that can lead to metastatic septic emboli and thrombocytopenia. However, current literature does not report an effect on other cell lines, which we report for the first time in this case.
A previously healthy young African American male presented with profound thrombocytopenia and leukopenia. He was tachypenic on presentation which progressed to respiratory failure requiring intubation. Blood cultures grew Fusobacterium necrophorum and imaging revealed internal jugular venous thrombosis. He was later diagnosed with Lemierre's syndrome. The patient was treated with zosyn and fully recovered with no residual deficits in hemoglobin, white cell count, platelet level, or renal function.
Lemierre's syndrome can cause severe disease in otherwise healthy patients via septicemia and widespread metastatic foci which can cause severe illness. While pulmonary complications are most common, there is little report of effects on other organ systems such as bone marrow and the kidneys. Clinicians should readily evaluate for Lemierre's syndrome as the complications are severe and can lead to multiorgan failure.
勒米尔综合征是一种罕见的口咽感染，可导致转移性脓毒性栓子和血小板减少。然而，目前的文献未报道其对其他细胞系的影响，我们在此病例中首次报告了这一情况。
一名既往健康的年轻非裔美国男性出现严重血小板减少和白细胞减少。就诊时呼吸急促，随后发展为呼吸衰竭，需要插管。血培养结果显示坏死梭杆菌生长，影像学检查显示颈内静脉血栓形成。他后来被诊断为勒米尔综合征。患者接受了哌拉西林他唑巴坦治疗，完全康复，血红蛋白、白细胞计数、血小板水平或肾功能均无残留缺陷。
勒米尔综合征可通过败血症和广泛的转移病灶在原本健康的患者中引起严重疾病，这些转移病灶可导致严重疾病。虽然肺部并发症最为常见，但关于其对骨髓和肾脏等其他器官系统影响的报道较少。由于并发症严重且可导致多器官功能衰竭，临床医生应随时对勒米尔综合征进行评估。
