Department of TCMs Pharmaceuticals & State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.
Department of TCMs Pharmaceuticals & State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, PR China.
Fitoterapia. 2021 Oct;154:105003. doi: 10.1016/j.fitote.2021.105003. Epub 2021 Jul 29.
Four new C-11 monosaccharide attached dammarane triterpenoid glycosides cypaliurusides SV (1-4), along with nine known dammarane triterpenoid glycosides (5-13) were isolated from a CHCl-soluble extract of the leaves of Cyclocarya paliurus. All characterized compounds were assayed for their cytotoxicities against HepG2 cells and 10 compounds were evaluated for the agonistic effects on sirtuin1 (SIRT1). The results showed that compounds 1, 5 and 6 were strongly cytotoxic in HepG2 cell line. Two dammarane triterpenoid glycosides 3 and 10 exhibited agonistic activities on SIRT1 with IC of 10 μM and 20 μM, respectively.
从青钱柳叶的 CHCl3 可溶部分中分离得到了四个新的 C-11 单糖连接的达玛烷三萜皂苷糖苷 cypaliurusides SV（1-4），以及九个已知的达玛烷三萜皂苷糖苷（5-13）。所有鉴定的化合物均针对 HepG2 细胞的细胞毒性进行了测试，其中 10 种化合物对 SIRT1 的激动作用进行了评估。结果表明，化合物 1、5 和 6 在 HepG2 细胞系中具有强烈的细胞毒性。两种达玛烷三萜皂苷糖苷 3 和 10 对 SIRT1 表现出激动活性，IC50 分别为 10 μM 和 20 μM。
