来自青钱柳叶的活性达玛烷三萜皂苷。
Bioactive dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus.
机构信息
College of Biotechnology, Guilin Medical University, Guilin, 541199, People's Republic of China.
College of Pharmacy, Guilin Medical University, Guilin, 541199, People's Republic of China.
出版信息
Phytochemistry. 2021 Mar;183:112618. doi: 10.1016/j.phytochem.2020.112618. Epub 2020 Dec 22.
Thirteen undescribed dammarane triterpenoid saponins (cypaliurusides A-M), including eleven seco-dammarane type triterpenoids, were isolated from Cyclocarya paliurus. Each of these compounds has the unique feature of having a monosaccharide attached to C-11, rather than C-12, compared to the same type of saponins found in this plant. The structures of them were determined by comprehensive analysis of 1D, 2D NMR and HRESIMS data. Cypaliuruside J showed significant α-glucosidase inhibitory effect with IC value of 2.22 ± 0.13 μM. In addition, Cypaliurusides F and K exhibited modest cytotoxic activities against selected human cancer cell lines in vitro, with IC values ranging from 4.61 ± 0.13 to 15.23 ± 3.88 μM.
从青钱柳中分离得到了 13 个未被描述的达玛烷三萜皂苷（cypaliurusides A-M），包括 11 个螺甾烷型三萜皂苷。与该植物中发现的同类型皂苷相比，这些化合物的独特之处在于它们的单糖连接在 C-11 上，而不是 C-12 上。通过对 1D、2D NMR 和 HRESIMS 数据的综合分析确定了它们的结构。Cypaliuruside J 对α-葡萄糖苷酶具有显著的抑制作用，IC 值为 2.22 ± 0.13 μM。此外，Cypaliurusides F 和 K 对体外选定的人癌细胞系表现出适度的细胞毒性活性，IC 值范围为 4.61 ± 0.13 至 15.23 ± 3.88 μM。
Zotero 插件