Hebei Key Laboratory of Information Transmission and Signal Processing, School of Information Science and Engineering, Yanshan University, Qinhuangdao 066004, China.
National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
Neuroscience. 2021 Sep 15;472:25-34. doi: 10.1016/j.neuroscience.2021.07.022. Epub 2021 Jul 30.
Studying the nonlinear synchronization of electroencephalogram (EEG) in type 2 diabetic mellitus (T2DM) to find the EEG characteristics related to cognitive impairment is beneficial to the early prevention and diagnosis of mild cognitive impairment. Correlation between probabilities of recurrence (CPR) is a nonlinear phase synchronization method based on recurrence and recurrence probability, which had shown its superiority in detecting epilepsy. In this study, CPR method was used for the first time to analyze the synchronization of eye-closed resting EEG signals with T2DM. The 27 participants were divided into amnesic mild cognitive impairment (aMCI) group (17 case) and control group (10 cases with age and education matched). The CPR values in two groups were statistically analyzed by Mann-Whitney U test, and the correlation between EEG synchronization and cognitive function was studied by Spearman's correlation. The results showed that aMCI group had lower CPR values at each electrode pair than control group, and two groups had decreased CPR values with the increase of the spatial distance of the electrode pair in inter hemispheric. The CPR values were significantly different in frontal, parietal and temporal regions in intra hemispheric between two groups. The CPR values of C3-F7, F4-C4 and FP2-T6 were significantly positively correlated with the MOCA values. This study showed that the synchronization values of EEG signals obtained by the CPR method were significantly different between aMCI and control group, and they were the EEG characteristics associated with cognitive impairment in T2DM.
研究 2 型糖尿病（T2DM）患者脑电（EEG）的非线性同步，寻找与认知障碍相关的 EEG 特征，有助于对轻度认知障碍的早期预防和诊断。相关概率（CPR）是一种基于递归和递归概率的非线性相位同步方法，已显示出在检测癫痫方面的优越性。本研究首次将 CPR 方法用于分析 T2DM 患者闭眼静息 EEG 信号的同步。27 名参与者被分为遗忘型轻度认知障碍（aMCI）组（17 例）和对照组（10 例，年龄和教育程度匹配）。采用 Mann-Whitney U 检验对两组的 CPR 值进行统计学分析，并采用 Spearman 相关分析研究 EEG 同步与认知功能的相关性。结果表明，aMCI 组在每个电极对上的 CPR 值均低于对照组，两组随着电极对空间距离的增加，CPR 值在大脑两半球之间呈下降趋势。两组在大脑半球内的额区、顶区和颞区的 CPR 值存在显著差异。C3-F7、F4-C4 和 FP2-T6 的 CPR 值与 MOCA 值呈显著正相关。本研究表明，CPR 方法获得的 EEG 信号同步值在 aMCI 组和对照组之间存在显著差异，是与 T2DM 认知障碍相关的 EEG 特征。
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