沙特阿拉伯族人群中地中海贫血的患病率。
Prevalence of thalassaemias in ethnic Saudi Arabians.
作者信息
Ganeshaguru K, Acquaye J K, Samuel A P, Hassounah F, Agyeiobese S, Azrai L M, Sejeny S A, Omer A
机构信息
Haemoglobinopathy Unit, King Fahd Medical Research Center, Jeddah, Saudi Arabia.
出版信息
Trop Geogr Med. 1987 Jul;39(3):238-43.
A study of the prevalence of alpha- and beta-thalassaemia and the sickle cell gene was carried out on 840 healthy adult male Saudi Arabians of different tribal origins. Complete blood count, haemoglobin electrophoresis and HbA2 estimation were carried out on all. Globin biosynthetic analysis was carried out on all 85 subjects with microcytic red cells and on 180 randomly selected subjects with normal red cell indices. The results showed prevalence of beta-thalassaemia of 3.0%, alpha/beta thalassaemia of 0.9%, alpha-thalassaemia of 43.3% and sickle trait of 5.7%. There were tribal variations in the prevalence of both alpha-thalassaemia and the sickle gene.
对840名来自不同部落的健康沙特成年男性进行了α和β地中海贫血以及镰状细胞基因的患病率研究。对所有人进行了全血细胞计数、血红蛋白电泳和HbA2测定。对所有85名小红细胞受试者和180名随机选择的红细胞指数正常的受试者进行了珠蛋白生物合成分析。结果显示，β地中海贫血患病率为3.0%，α/β地中海贫血患病率为0.9%，α地中海贫血患病率为43.3%，镰状细胞性状患病率为5.7%。α地中海贫血和镰状细胞基因的患病率存在部落差异。
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