[十四烷酰佛波醇-13-乙酸酯对培养成纤维细胞形态和细胞骨架的影响]

[Changes in the form and cytoskeleton of cultured fibroblasts as affected by 12-tetradecanoylphorbol-13-acetate].

作者信息

Dugina V B, Svitkina T M, Vasil'ev Iu M, Gel'fand I M

出版信息

Tsitologiia. 1987 Oct;29(10):1138-43.

Abstract

A new type of reorganization of cytoskeleton induced by 12-o-tetradecanoyl-phorbol-13-acetate motility: division of the cell into an actin-rich active part and stable processes with numerous microtubules. Such a phenomenon was observed under a short-term influence of TPA on different lines of cultured fibroblasts: NRK, Balb/C 3T3, C-103, C-84, CAK-7. The effect of TPA was reversible and suppressed by cytochalasin B and colcemid. TPA is supposed to induce changes in the interaction between actin cortex and microtubule system.

摘要

12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯诱导的一种新型细胞骨架重组：细胞分为富含肌动蛋白的活跃部分和具有大量微管的稳定突起。在TPA对不同系培养的成纤维细胞（NRK、Balb/C 3T3、C - 103、C - 84、CAK - 7）的短期影响下观察到了这种现象。TPA的作用是可逆的，并且被细胞松弛素B和秋水仙酰胺抑制。据推测，TPA会诱导肌动蛋白皮层与微管系统之间相互作用的变化。

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