[Changes in the form and cytoskeleton of cultured fibroblasts as affected by 12-tetradecanoylphorbol-13-acetate].

A new type of reorganization of cytoskeleton induced by 12-o-tetradecanoyl-phorbol-13-acetate motility: division of the cell into an actin-rich active part and stable processes with numerous microtubules. Such a phenomenon was observed under a short-term influence of TPA on different lines of cultured fibroblasts: NRK, Balb/C 3T3, C-103, C-84, CAK-7. The effect of TPA was reversible and suppressed by cytochalasin B and colcemid. TPA is supposed to induce changes in the interaction between actin cortex and microtubule system.