高迁移率族蛋白 B1 水平可能与白塞病的疾病活动有关。
High mobility group box-1 levels may be associated with disease activity of Behcet's disease.
机构信息
Department of Internal Medical Sciences, Faculty of Medicine, Ankara University, Ankara, Turkey.
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine,Ankara University, Ankara, Turkey.
出版信息
Turk J Med Sci. 2021 Oct;51(5):2690-2697. doi: 10.3906/sag-2101-116. Epub 2021 Oct 21.
BACKGROUND
High mobility group box- 1 (HMGB- 1) is a nuclear protein acting as a proinflammatory molecule. The serum HMGB- 1 levels were found elevated in chronic inflammatory diseases. In this cross-sectional study, serum HMGB- 1 levels in Behcet's disease (BD) patients and healthy controls (HC) were studied. Also, its association with disease activity scores and clinical findings were evaluated.
METHODS
Ninety BD patients and 50 age-sex matched HC were included in the study. Disease activity scores were assessed by Behcet Disease Current Activity Form (BDCAF) and Behcet Syndrome Activity Score (BSAS). Serum HMGB- 1 levels were measured using a commercial ELISA kit. A p value of < 0.05 was considered to be statistically significant.
RESULTS
Serum HMGB- 1 levels were significantly higher in BD than in HC (43.26 pg/mL and 16.73 pg/mL; p < 0.001, respectively). Serum HMGB- 1 levels were statistically significantly associated with presence of erythema nodosum (EN) and genital ulcers in the last one month prior to recruitment (p = 0.041 and p < 0.001, respectively). BDCAF and BSAS scores were positively correlated with serum HMGB- 1 level ( p = 0.03 and p = 0.02, respectively).
DISCUSSION
HMGB - 1 may play a role in the development of BD. Also, due to its positive correlation with disease activity indices, it can be used as a novel disease activity parameter in BD.
背景
高迁移率族蛋白 B1（HMGB-1）是一种核蛋白，作为一种促炎分子。在慢性炎症性疾病中发现血清 HMGB-1 水平升高。在这项横断面研究中，研究了 Behcet 病（BD）患者和健康对照者（HC）的血清 HMGB-1 水平，并评估了其与疾病活动评分和临床发现的关系。
方法
纳入 90 例 BD 患者和 50 例年龄性别匹配的 HC。采用 Behcet 疾病活动表（BDCAF）和 Behcet 综合征活动评分（BSAS）评估疾病活动评分。使用商业 ELISA 试剂盒测量血清 HMGB-1 水平。p 值<0.05 被认为具有统计学意义。
结果
BD 患者血清 HMGB-1 水平明显高于 HC（分别为 43.26 pg/ml 和 16.73 pg/ml；p<0.001）。血清 HMGB-1 水平与招募前一个月内存在结节性红斑（EN）和生殖器溃疡呈统计学显著相关（p=0.041 和 p<0.001，分别）。BDCAF 和 BSAS 评分与血清 HMGB-1 水平呈正相关（p=0.03 和 p=0.02，分别）。
讨论
HMGB-1 可能在 BD 的发病机制中起作用。此外，由于其与疾病活动指数呈正相关，因此可作为 BD 的新型疾病活动参数。
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