评估白塞病患者的抑郁、焦虑和疲劳情况。

An evaluation of depression, anxiety and fatigue in patients with Behçet's disease.

机构信息

Department of Rheumatology, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Department of Rheumatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.

出版信息

Int J Rheum Dis. 2019 Jun;22(6):974-979. doi: 10.1111/1756-185X.13411. Epub 2018 Nov 5.

DOI:10.1111/1756-185X.13411

PMID:30398004

Abstract

OBJECTIVES

Behçet's disease (BD) is a type of systemic vasculitis and inflammatory disease of unknown etiology, which is associated with fatigue and lower quality of life (QoL). The aim of this study was to assess the relationship between Behçet's Disease Current Activity Form (BDCAF) and Behçet's Disease Quality of Life (BDQoL), depression, anxiety and fatigue in Behçet's disease.

METHODS

We conducted a cross-sectional study of 155 BD patients and 107 healthy subjects in a single center over a 1 year period. All participants completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, and the Hospital Anxiety and Depression (HADS) scale. Disease activity in the BD patients was assessed using the BDCAF, and the physician's global assessment (PGA). BD patients also completed the BDQoL questionnaire.

RESULTS

There was no significant difference in age and gender between the groups. BD patients had significantly higher HADS-anxiety (HADS-A), HADS-depression (HADS-D) and MAF scores than the healthy control group (P < 0.05). BD patients with active disease had significantly higher MAF and HADS-A scores compared to inactive BD patients (P < 0.05). MAF scores showed positive correlations with HADS-A, HADS-D, BDCAF and BDQoL.

CONCLUSIONS

Fatigue and anxiety are common in clinically active BD patients compared with healthy control subjects and inactive BD patients.

摘要

目的

白塞病（BD）是一种病因不明的系统性血管炎和炎症性疾病，与疲劳和生活质量（QoL）下降有关。本研究旨在评估 Behçet 疾病活动表（BDCAF）与 Behçet 疾病生活质量（BDQoL）、抑郁、焦虑和疲劳之间的关系。

方法

我们在 1 年内对 155 名 BD 患者和 107 名健康对照者进行了单中心横断面研究。所有参与者都完成了多维疲劳评估（MAF）问卷和医院焦虑和抑郁量表（HADS）。BD 患者的疾病活动度采用 BDCAF 和医生整体评估（PGA）进行评估。BD 患者还完成了 BDQoL 问卷。

结果

两组在年龄和性别上无显著差异。BD 患者的 HADS 焦虑（HADS-A）、HADS 抑郁（HADS-D）和 MAF 评分均明显高于健康对照组（P<0.05）。活动期 BD 患者的 MAF 和 HADS-A 评分明显高于非活动期 BD 患者（P<0.05）。MAF 评分与 HADS-A、HADS-D、BDCAF 和 BDQoL 呈正相关。