Institute of Molecular Bioimaging and Physiology (IBFM), National Research Council (CNR), Section of Germaneto, Catanzaro, Italy.
Department of Medical and Surgical Sciences, Institute of Neurology, University "Magna Graecia, " Germaneto, Catanzaro, Italy.
J Parkinsons Dis. 2021;11(4):1475-1489. doi: 10.3233/JPD-212726.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting 5%of the elderly population. Currently, the diagnosis of PD is mainly based on clinical features and no definitive diagnostic biomarkers have been identified. The discovery of biomarkers at the earliest stages of PD is of extreme interest. This review focuses on the current findings in the field of circulating non-coding RNAs in PD. We briefly describe the more established circulating biomarkers in PD and provide a more thorough review of non-coding RNAs, in particular microRNAs, long non-coding RNAs and circular RNAs, differentially expressed in PD, highlighting their potential for being considered as biomarkers for diagnosis. Together, these studies hold promise for the use of peripheral biomarkers for the diagnosis of PD.
帕金森病（PD）是第二常见的神经退行性疾病，影响 5%的老年人口。目前，PD 的诊断主要基于临床特征，尚未确定明确的诊断生物标志物。在 PD 的早期发现生物标志物具有极大的兴趣。这篇综述重点介绍了 PD 中循环非编码 RNA 领域的当前发现。我们简要描述了 PD 中更成熟的循环生物标志物，并更全面地综述了非编码 RNA，特别是 microRNAs、长非编码 RNA 和环状 RNA，它们在 PD 中的差异表达，强调了它们作为诊断生物标志物的潜力。这些研究共同为使用外周生物标志物诊断 PD 提供了希望。
