帕金森病中长非编码 RNA 的纵向失调。
Longitudinal dysregulation of long non-coding RNAs in Parkinson's disease.
机构信息
Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7602, South Africa.
South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town 7602, South Africa.
出版信息
Exp Biol Med (Maywood). 2023 Oct;248(20):1780-1784. doi: 10.1177/15353702231198078. Epub 2023 Sep 26.
Long non-coding RNAs (lncRNAs) have been suggested as potential biomarkers for Parkinson's disease (PD). This study aimed to identify blood-based lncRNA transcripts that are dysregulated in PD over time and could serve as peripheral biomarkers. Using RNA-sequencing data from the Parkinson's Progression Markers Initiative, differential expression between case and control groups at five different time points was detected, and pathway analysis was conducted. Seven transcripts, not previously linked to PD, were consistently dysregulated across all time points, while PD-linked lncRNAs were dysregulated at some but not all time points. Pathway analysis highlighted pathways, known to be affected in PD. This suggested that dysregulated lncRNA transcripts could play a role in PD pathogenesis by affecting well-known PD pathways and highlighted their potential as longitudinal biomarkers for PD. Further studies are needed to validate these findings and explore the potential use of identified lncRNAs as diagnostic and therapeutic targets.
长链非编码 RNA（lncRNA）被认为是帕金森病（PD）的潜在生物标志物。本研究旨在鉴定血液中随时间变化而失调的 lncRNA 转录本，这些转录本可作为外周生物标志物。使用帕金森病进展标志物倡议的 RNA-seq 数据，在五个不同时间点检测病例组和对照组之间的差异表达，并进行通路分析。七个先前与 PD 无关的转录本在所有时间点均持续失调，而与 PD 相关的 lncRNA 仅在某些时间点而非所有时间点失调。通路分析突出了已知在 PD 中受影响的通路。这表明失调的 lncRNA 转录本可能通过影响已知的 PD 通路在 PD 发病机制中发挥作用，并强调了它们作为 PD 纵向生物标志物的潜力。需要进一步的研究来验证这些发现，并探索鉴定出的 lncRNAs 作为诊断和治疗靶点的潜在用途。
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