The Second Affiliated Hospital of Anhui Medical University, Hefei 230000, China.
Comput Math Methods Med. 2021 Jul 19;2021:8361504. doi: 10.1155/2021/8361504. eCollection 2021.
Red blood cell distribution width (RDW) is increased in a variety of inflammatory-related diseases. However, there is no report of its clinical significance in poststroke depression (PSD). This study explores the clinical significance of RDW in PSD patients.
A total of 185 patients with first-ever acute ischaemic stroke (AIS) in the Second Hospital of Anhui Medical University were chosen as subjects. A retrospective observational study was conducted from February 2019 to February 2020. PSD patients were diagnosed at 6 months after stroke based on the Diagnostic and Statistical Manual of Mental Disorders-IV criteria. Clinical and laboratory data were obtained from all patients. Coefficient of Variation (RDW-CV) and standard deviation (RDW-SD) were used to statistically report the performance of red blood cell distribution width.
At the 6-month follow-up, 46 patients were diagnosed with PSD. Compared with non-PSD patients, PSD patients exhibited an increase in RDW-CV and RDW-SD, which positively correlated with serum interleukin 6 (IL-6) concentrations. In PSD patients, only RDW-SD demonstrated a consistent positive association with the Hamilton Rating Scale for Depression (HAM-D) scores at 6 months after admission. RDW-CV, RDW-SD, and IL-6 were recognized as independent predictors of PSD. The area under the receiver operating characteristic (ROC) curve (AUC) of RDW-SD was 0.796 (95% CI: 0.731-0.852) for the prediction of PSD, which was superior to that of RDW-CV. The specificity for predicting PSD was 60.43%, and the sensitivity was 91.30% if RDW-SD was higher than 43.80 fL.
RDW-SD is a simple, inexpensive, rapid, and easily accessible parameter that can be used to predict PSD in patients with stroke.
红细胞分布宽度（RDW）在各种炎症相关疾病中增加。然而，目前尚无其在卒中后抑郁（PSD）中的临床意义的报道。本研究旨在探讨 RDW 在 PSD 患者中的临床意义。
选择安徽医科大学第二附属医院 185 例首次急性缺血性脑卒中（AIS）患者作为研究对象。回顾性观察性研究于 2019 年 2 月至 2020 年 2 月进行。根据《精神障碍诊断与统计手册第四版》标准，在卒中后 6 个月时诊断 PSD 患者。从所有患者中获取临床和实验室数据。采用变异系数（RDW-CV）和标准差（RDW-SD）来统计报告红细胞分布宽度的表现。
在 6 个月的随访中，46 例患者被诊断为 PSD。与非 PSD 患者相比，PSD 患者的 RDW-CV 和 RDW-SD 增加，且与血清白细胞介素 6（IL-6）浓度呈正相关。在 PSD 患者中，只有 RDW-SD 与入院后 6 个月的汉密尔顿抑郁量表（HAM-D）评分呈一致的正相关。RDW-CV、RDW-SD 和 IL-6 被认为是 PSD 的独立预测因子。RDW-SD 预测 PSD 的受试者工作特征（ROC）曲线下面积（AUC）为 0.796（95%CI：0.731-0.852），优于 RDW-CV。预测 PSD 的特异性为 60.43%，当 RDW-SD 高于 43.80 fL 时，敏感性为 91.30%。
RDW-SD 是一种简单、经济、快速且易于获得的参数，可用于预测卒中患者的 PSD。
