Matasariu Daniela Roxana, Ursache Alexandra, Himiniuc Loredana, Toma Bogdan, Boiculese Vasile Lucian, Rudisteanu Dorina, Dumitrascu Irina
Department of Obstetrics and Gynecology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
Department of Preventive Medicine and Interdisciplinarity Medical Informatics and Biostatistics, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
Exp Ther Med. 2021 Sep;22(3):955. doi: 10.3892/etm.2021.10387. Epub 2021 Jul 6.
A major myomectomy-associated problem is excessive blood loss. The aim of the present study was to evaluate the effect of glypressin on blood loss during laparoscopic myomectomy (LM) in women with uterine myomas. A total of 188 women scheduled for LM for uterine myomas were divided into two groups. The one group of women (n=64) received a 5-ml intramyometrial injection of glypressin 0.2 mg/ml (glypressin group; group 1). The other group of women (n=124) (group 2) had an LM performed without any other method to reduce blood loss. The decrease in postoperative hemoglobin (Hb), hematocrit (Ht), morbidity and duration of hospital stay were assessed. The results revealed that Hb and Ht (as it was presumed) exhibited similar changes in our study. Statistically significant differences (P<0.05) were obtained between the two groups in terms of Hb and Ht; after LM both Hb and Ht were decreased. In conclusion, the impact of glypressin administration in hemorrhage control in uterine leiomyomas may establish new future perspectives, regarding its administration in gynecological hemorrhagic pathologies.
子宫肌瘤剔除术的一个主要相关问题是失血过多。本研究的目的是评估加压素对子宫肌瘤女性患者腹腔镜子宫肌瘤剔除术（LM）期间失血的影响。共有188例计划接受LM治疗子宫肌瘤的女性被分为两组。一组女性（n = 64）接受5毫升子宫肌层内注射0.2毫克/毫升的加压素（加压素组；第1组）。另一组女性（n = 124）（第2组）进行LM手术时未采用任何其他减少失血的方法。评估术后血红蛋白（Hb）、血细胞比容（Ht）、发病率和住院时间的降低情况。结果显示，在我们的研究中Hb和Ht（正如推测的那样）呈现出相似的变化。两组在Hb和Ht方面存在统计学显著差异（P<0.05）；LM术后Hb和Ht均降低。总之，加压素给药对子宫平滑肌瘤出血控制的影响可能为其在妇科出血性疾病中的应用开创未来新的前景。
