Petreanu Cornel, Croitoru Alina, Gibu Alexandru, Zariosu Alexandru, Bacalbasa Nicolae, Balescu Irina, Diaconu Camelia, Stiru Ovidiu, Dimitriu Mihai, Cretoiu Dragos, Savu Cornel
Department of Thoracic Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Thoracic Surgery, 'Marius Nasta' National Institute of Pneumology, 050159 Bucharest, Romania.
Exp Ther Med. 2021 Sep;22(3):957. doi: 10.3892/etm.2021.10389. Epub 2021 Jul 6.
Pulmonary aspergillosis in patients with respiratory failure can severely affect the pulmonary functional status and may aggravate it through pulmonary suppuration, by recruitment of new parenchyma and hemoptysis, which can sometimes be massive, with lethal risk by flooding the bronchus. The treatment consists of a combination of medical therapy, surgery and interventional radiology. In small lesions, less than 2-3 cm, medical therapy methods may be sufficient; however, in invasive forms (larger than 3 cm) surgical resection is necessary. Surgical resection is the ideal treatment; nevertheless, when lung function does not allow it, action must be taken to eliminate the favorable conditions of the infection. In such cases, whenever the lung cavity is peripheral, a cavernostomy may be performed. Four cases of lung cavernous lesions colonized with aspergillus, in which the need for a therapeutic gesture was imposed by repeated small to medium hemoptysis and by the progression of respiratory failure, were evaluated, one of which is presented in the current study. Cavernostomy closure can be realized either surgically with muscle flap or spontaneously by scarring, after closure of the bronchial fistulas by epithelization and granulation. There were no recurrences of hemoptysis or suppurative phenomena. There was one death, a patient with severe respiratory failure caused by superinfection with nonspecific germs. However, in the case presented in this study, the patient recovered following cavernostomy, which seems to be an effective and safe method for cases in which lung resection is not feasible.
呼吸衰竭患者的肺曲霉病可严重影响肺功能状态,并可能通过肺化脓、新实质的募集和咯血(有时咯血量大,可因淹没支气管而有致命风险)使其恶化。治疗包括药物治疗、手术和介入放射学相结合。对于小于2 - 3厘米的小病灶,药物治疗方法可能就足够了;然而,对于侵袭性病灶(大于3厘米),手术切除是必要的。手术切除是理想的治疗方法;然而,当肺功能不允许时,必须采取措施消除感染的有利条件。在这种情况下,只要肺空洞位于周边,可进行空洞造口术。评估了4例曲霉定植的肺空洞性病变病例,这些病例因反复少量至中等量咯血和呼吸衰竭进展而需要采取治疗措施,其中1例在本研究中呈现。空洞造口术的闭合可通过带肌瓣手术实现,也可在支气管瘘通过上皮化和肉芽组织闭合后通过瘢痕形成自发实现。咯血或化脓现象均未复发。有1例死亡,是1名因非特异性病菌二重感染导致严重呼吸衰竭的患者。然而,在本研究呈现的病例中,患者在空洞造口术后康复,对于无法进行肺切除的病例,空洞造口术似乎是一种有效且安全的方法。