Wang Feiyang, Huang Li, Zhang Jinyan, Fan Junwei, Wu Heshui, Xu Junming
Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Pancreatic Surgery, Wuhan Uniom Hospital, Huazhong University of Science and Technology, Wuhan, China.
J Cancer. 2021 Jul 3;12(17):5338-5344. doi: 10.7150/jca.60340. eCollection 2021.
Pancreatic cancer (PC) is one of the most aggressive and lethal malignancies in the world. High cholesterol intake may have a certain association with an elevated risk of PC, though dyslipidemia in PC patients has rarely been reported. In this study, we compared serum lipids levels between PC and non-PC tumor patients and assessed their prognostic value in PC. 271 patients treated at Wuhan Union Hospital from January 2012 to December 2016 and 204 individuals at Shanghai General Hospital from January 2018 to December 2019 were recruited. Their demographic parameters, laboratory data, pathological information, and clinical outcomes were extracted and analyzed. The mRNA expressions of related lipoprotein, low density lipoprotein receptor (LDLR) and high density lipoprotein binding protein (HDLBP), in PC tissues and paired noncancerous tissues and follow-up information were assessed based on the GEO database (GSE15471 and GSE62165) and TCGA database. A total of 172 non-PC tumor patients and 260 PC patients were finally eligible for our analysis. PC patients exhibited higher levels of serum triglyceride, cholesterol, and low-density lipoprotein (LDL) and a lower serum high-density lipoprotein (HDL) level on admission versus the non-PC tumor group. In PC patients, LDLR mRNA expression was upregulated, and HDLBP mRNA expression was downregulated in cancerous tissues compared to these levels in paired noncancerous tissues. The survival analysis revealed that dyslipidemia had a non-significant association with a poor prognosis, but PC patients with a high LDLR level were at risk of poor survival. Dyslipidemia is detected in PC patients but has a non-significant relation to PC prognosis. However, LDLR may be a potential predictive marker for PC prognosis.
胰腺癌（PC）是全球最具侵袭性和致命性的恶性肿瘤之一。高胆固醇摄入可能与PC风险升高存在一定关联，尽管PC患者的血脂异常情况鲜有报道。在本研究中，我们比较了PC患者与非PC肿瘤患者的血脂水平，并评估了它们在PC中的预后价值。招募了2012年1月至2016年12月在武汉协和医院接受治疗的271例患者以及2018年1月至2019年12月在上海交通大学医学院附属瑞金医院的204例患者。提取并分析了他们的人口统计学参数、实验室数据、病理信息和临床结局。基于基因表达综合数据库（GEO数据库，GSE15471和GSE62165）和癌症基因组图谱（TCGA）数据库评估了PC组织及配对的癌旁组织中相关脂蛋白、低密度脂蛋白受体（LDLR）和高密度脂蛋白结合蛋白（HDLBP）的mRNA表达以及随访信息。最终共有172例非PC肿瘤患者和260例PC患者纳入我们的分析。与非PC肿瘤组相比，PC患者入院时血清甘油三酯、胆固醇和低密度脂蛋白（LDL）水平较高，血清高密度脂蛋白（HDL）水平较低。在PC患者中，与配对的癌旁组织相比，癌组织中LDLR mRNA表达上调，HDLBP mRNA表达下调。生存分析显示，血脂异常与预后不良的关联不显著，但LDLR水平高的PC患者生存风险较高。PC患者存在血脂异常，但与PC预后无显著关系。然而，LDLR可能是PC预后的潜在预测标志物。
