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自身抗体对 p53、MMP-7 和 Hsp70 作为非黑色素瘤皮肤癌检测的潜在生物标志物。

Autoantibodies against p53, MMP-7, and Hsp70 as Potential Biomarkers for Detection of Nonmelanoma Skin Cancers.

机构信息

Department of Dermatology and Venereology, Affiliated Shantou Hospital of Sun Yat-sen University, 114 Waima Road, Shantou 515041, China.

Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou 515041, China.

出版信息

Dis Markers. 2021 Jul 10;2021:5592693. doi: 10.1155/2021/5592693. eCollection 2021.

DOI:10.1155/2021/5592693
PMID:34336006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8289574/
Abstract

Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are two predominant histological types of nonmelanoma skin cancer (NMSC), lacking effective early diagnostic markers. In this study, we assessed the diagnostic value of autoantibodies against p53, MMP-7, and Hsp70 in skin SCC and BCC. ELISA was performed to detect levels of autoantibodies in sera from 101 NMSC patients and 102 normal controls, who were recruited from the Cancer Hospital of Shantou University Medical College. A receiver operator characteristic curve was used to evaluate the diagnostic value. The serum levels of autoantibodies against p53, MMP-7, and Hsp70 were higher in NMSCs than those in the normal controls (all < 0.01). The AUC of the three-autoantibody panel was 0.841 (95% CI: 0.788-0.894) with the sensitivity and specificity of 60.40% and 91.20% when differentiating NMSCs from normal controls. Furthermore, measurement of this panel could differentiate early-stage skin cancer patients from normal controls (AUC: 0.851; 95% CI: 0.793-0.908). Data from Oncomine showed that the level of p53 mRNA was elevated in BCC ( < 0.05), and the Hsp70 mRNA was upregulated in SCC ( < 0.001). This serum three-autoantibody panel might function in assisting the early diagnosis of NMSC.

摘要

基底细胞癌 (BCC) 和鳞状细胞癌 (SCC) 是非黑色素瘤皮肤癌 (NMSC) 的两种主要组织学类型，缺乏有效的早期诊断标志物。在这项研究中，我们评估了针对 p53、MMP-7 和 Hsp70 的自身抗体在皮肤 SCC 和 BCC 中的诊断价值。通过酶联免疫吸附试验 (ELISA) 检测了来自汕头大学医学院附属肿瘤医院的 101 名 NMSC 患者和 102 名正常对照者血清中自身抗体的水平。使用受试者工作特征曲线来评估诊断价值。NMSCs 患者血清中针对 p53、MMP-7 和 Hsp70 的自身抗体水平高于正常对照组（均 < 0.01）。三自身抗体组合的 AUC 为 0.841（95%CI：0.788-0.894），用于区分 NMSCs 与正常对照组时，灵敏度和特异性分别为 60.40%和 91.20%。此外，该组合的测量可将早期皮肤癌患者与正常对照组区分开（AUC：0.851；95%CI：0.793-0.908）。Oncomine 数据显示，BCC 中 p53mRNA 水平升高（ < 0.05），SCC 中 Hsp70mRNA 上调（ < 0.001）。该血清三自身抗体组合可能有助于 NMSC 的早期诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/fc6fe9558600/DM2021-5592693.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/1f54854212b9/DM2021-5592693.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/e0ba0b09fb1d/DM2021-5592693.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/bb07a413d5d3/DM2021-5592693.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/515057e1e818/DM2021-5592693.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/6cee96cc41ea/DM2021-5592693.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/fc6fe9558600/DM2021-5592693.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/1f54854212b9/DM2021-5592693.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/e0ba0b09fb1d/DM2021-5592693.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/bb07a413d5d3/DM2021-5592693.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/515057e1e818/DM2021-5592693.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/6cee96cc41ea/DM2021-5592693.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d475/8289574/fc6fe9558600/DM2021-5592693.006.jpg

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