0.5% 局部用眼科丙美卡因和盐酸丁卡因滴入后作用持续时间及角膜接触阈值（CTT）的年龄和性别差异

Age and Sex Variation in the Duration of Action and Corneal Touch Threshold (CTT) following Instillation of 0.5% Topical Ophthalmic Proparacaine and Tetracaine Hydrochlorides.

作者信息

Kyei Samuel, Abaka Dadzie Nana Yaw, Zaabaar Ebenezer, Asamoah Dwomoh Kwasi Antwi, Asiedu Kofi

机构信息

Department of Optometry and Vision Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.

The Eye Clinic, LEKMA Hospital, Teshie, Accra, Ghana.

出版信息

J Ophthalmol. 2021 Jul 14;2021:8661098. doi: 10.1155/2021/8661098. eCollection 2021.

DOI:10.1155/2021/8661098

PMID:34336260

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8294970/

Abstract

PURPOSE

We investigated the effect of age and sex on corneal touch threshold (CTT) and duration of action following administration of 0.5% topical ophthalmic proparacaine and tetracaine hydrochlorides.

METHODS

A prospective, randomized, subject-masked, crossover study design was used. Two hundred and forty human volunteers were enrolled in the study. Corneal touch threshold (CTT) was determined using a Cochet-Bonnet esthesiometer. CTT was measured every 15 seconds for the first 1-minute and at 5-minute intervals subsequently for a period of 40 minutes after the application of each anesthetic. CTT and duration of action of the ophthalmic solutions were tested for statistical significance using repeated measures ANOVA.

RESULTS

The total duration of effect was 20 minutes for females and 25 minutes for males for both anesthetics. The total duration of the effect of both solutions decreased with increasing age; however, elderly participants had the longest duration (5 minutes) of the maximal effect (minimum CTT) of the two ophthalmic preparations. There was a significant influence of sex, F (2.39, 569.65) = 2.86, =0.04; F (3.48, 828.19) = 4.41, =0.003, and age, F (4.78, 566.18) = 8.97, < 0.001; F (7.19, 852.56) = 20.55, < 0.001 on CTT following application of proparacaine hydrochloride and tetracaine hydrochloride, respectively.

CONCLUSION

CTT and duration of anesthetic effect after instillation of 1 drop of 0.5% proparacaine hydrochloride and 0.5% tetracaine hydrochloride vary based on sex and age.

摘要

目的

我们研究了年龄和性别对0.5%的局部眼科丙美卡因和盐酸丁卡因给药后的角膜触觉阈值（CTT）及作用持续时间的影响。

方法

采用前瞻性、随机、受试者盲法、交叉研究设计。240名人类志愿者参与了该研究。使用科谢-博内触觉计测定角膜触觉阈值（CTT）。在每次应用麻醉剂后，最初1分钟内每15秒测量一次CTT，随后40分钟内每隔5分钟测量一次。使用重复测量方差分析对眼科溶液的CTT和作用持续时间进行统计学显著性检验。

结果

两种麻醉剂对女性的总作用持续时间均为20分钟，对男性均为25分钟。两种溶液的总作用持续时间均随年龄增长而缩短；然而，老年参与者对两种眼科制剂的最大作用（最低CTT）持续时间最长（5分钟）。性别对应用盐酸丙美卡因和盐酸丁卡因后的CTT有显著影响，F（2.39，569.65）=2.86，P=0.04；F（3.48，828.19）=4.41，P=0.003，年龄也有显著影响，F（4.78，566.18）=8.97，P<0.001；F（7.19，852.56）=20.55，P<0.001。