Binder Daniel R, Herring Ian P
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442, USA.
Am J Vet Res. 2006 Oct;67(10):1780-2. doi: 10.2460/ajvr.67.10.1780.
To determine duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in domestic shorthair (DSH) cats.
20 clinically normal DSH cats.
Baseline corneal touch threshold (CCT) was established by use of a Cochet-Bonnet aesthesiometer. Treatment consisted of a single 50-microL topical application of an ophthalmic preparation of 0.5% proparacaine solution to a randomly selected eye of each cat. The corneal touch threshold was assessed 1 and 5 minutes after application to the cornea and at 5- minute intervals thereafter for 60 minutes.
Corneal sensitivity, as determined by Cochet-Bonnet aesthesiometry, was significantly reduced from baseline for 25 minutes following topical administration of ophthalmic proparacaine. Maximal anesthetic effect lasted 5 minutes.
As determined by Cochet-Bonnet aesthesiometry, duration of anesthetic effects on the cornea induced by a single topical application of an ophthalmic preparation of 0.5% proparacaine solution in DSH cats is considerably shorter than the reported duration of corneal anesthesia in dogs.
确定在国内短毛猫（DSH）中局部应用0.5%盐酸丙美卡因溶液后的角膜麻醉持续时间。
20只临床正常的DSH猫。
使用科谢-博内（Cochet-Bonnet）麻醉计确定基线角膜触觉阈值（CCT）。治疗方法是对每只猫的一只随机选择的眼睛局部应用一滴50微升的0.5%丙美卡因溶液眼科制剂。在将药物应用于角膜后1分钟和5分钟以及之后每5分钟评估一次角膜触觉阈值，持续60分钟。
通过科谢-博内麻醉测量法确定，局部应用眼科丙美卡因后25分钟内角膜敏感性较基线显著降低。最大麻醉效果持续5分钟。
通过科谢-博内麻醉测量法确定，在DSH猫中单次局部应用0.5%丙美卡因溶液眼科制剂对角膜产生的麻醉作用持续时间明显短于报道的犬角膜麻醉持续时间。
