药物处置中的性别差异。
Sex differences in drug disposition.
作者信息
Soldin Offie P, Chung Sarah H, Mattison Donald R
机构信息
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
出版信息
J Biomed Biotechnol. 2011;2011:187103. doi: 10.1155/2011/187103. Epub 2011 Feb 23.
Abstract
Physiological, hormonal, and genetic differences between males and females affect the prevalence, incidence, and severity of diseases and responses to therapy. Understanding these differences is important for designing safe and effective treatments. This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men and women.
摘要
男性和女性之间的生理、激素及基因差异会影响疾病的患病率、发病率、严重程度以及对治疗的反应。了解这些差异对于设计安全有效的治疗方法很重要。本文总结了影响药物处置的性别差异，并对适用于男性和女性的临床药理学进行了总体比较。
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