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Sex differences in drug disposition.药物处置中的性别差异。
J Biomed Biotechnol. 2011;2011:187103. doi: 10.1155/2011/187103. Epub 2011 Feb 23.
2
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3
Sex-related differences in drug disposition in man.人类药物处置中的性别差异。
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Sex differences in pharmacokinetics and pharmacodynamics.药代动力学和药效学中的性别差异。
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Significant Improvement in Bioavailability and Therapeutic Efficacy of Mebendazole Oral Nano-Systems Assessed in a Murine Model with Extreme Phenotypes of Susceptibility to .在对甲苯咪唑口服纳米系统的生物利用度和治疗效果进行评估的极端易感性小鼠模型中，其生物利用度和治疗效果有显著改善。
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本文引用的文献

1
The path to personalized medicine.个性化医疗之路。
N Engl J Med. 2010 Jul 22;363(4):301-4. doi: 10.1056/NEJMp1006304. Epub 2010 Jun 15.
2
The pharmacokinetics of fluconazole in healthy Chinese adult volunteers: influence of ethnicity and gender.氟康唑在健康中国成年志愿者中的药代动力学：种族和性别影响。
J Clin Pharm Ther. 2010 Apr;35(2):231-7. doi: 10.1111/j.1365-2710.2009.01097.x.
3
Quantitative prediction of intestinal metabolism in humans from a simplified intestinal availability model and empirical scaling factor.从简化的肠可及性模型和经验性缩放因子定量预测人体肠道代谢。
Drug Metab Dispos. 2010 Jul;38(7):1230-7. doi: 10.1124/dmd.109.029322. Epub 2010 Mar 30.
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Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework.基于证据的血液乙醇消除率调查及其在法医学中的应用。
Forensic Sci Int. 2010 Jul 15;200(1-3):1-20. doi: 10.1016/j.forsciint.2010.02.021. Epub 2010 Mar 20.
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Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity.细胞色素 P450 2C8 和 3A5 的多态性与紫杉醇神经毒性相关。
Pharmacogenomics J. 2011 Apr;11(2):121-9. doi: 10.1038/tpj.2010.13. Epub 2010 Mar 9.
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Membrane transporters in drug development.药物开发中的膜转运体。
Nat Rev Drug Discov. 2010 Mar;9(3):215-36. doi: 10.1038/nrd3028.
7
Influence of body weight and gender on the pharmacokinetics, pharmacodynamics, and antihypertensive efficacy of aliskiren.体重和性别对阿利克仑的药代动力学、药效学和降压疗效的影响。
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Gender differences in drug toxicity.药物毒性的性别差异。
Trends Pharmacol Sci. 2010 Mar;31(3):108-14. doi: 10.1016/j.tips.2009.12.001. Epub 2010 Feb 1.
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Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: an updated review.抗抑郁药的药代动力学和药效学中的性别差异：最新综述。
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Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity.采用 LC-MS/MS 定量测定人尿液中的皮质醇和 6β-羟基皮质醇，并对代谢比值作为 CYP3A 活性生物标志物进行性别特异性评估。
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药物处置中的性别差异。

Sex differences in drug disposition.

作者信息

Soldin Offie P, Chung Sarah H, Mattison Donald R

机构信息

Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.

出版信息

J Biomed Biotechnol. 2011;2011:187103. doi: 10.1155/2011/187103. Epub 2011 Feb 23.

DOI:10.1155/2011/187103
PMID:21403873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3051160/
Abstract

Physiological, hormonal, and genetic differences between males and females affect the prevalence, incidence, and severity of diseases and responses to therapy. Understanding these differences is important for designing safe and effective treatments. This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men and women.

摘要

男性和女性之间的生理、激素及基因差异会影响疾病的患病率、发病率、严重程度以及对治疗的反应。了解这些差异对于设计安全有效的治疗方法很重要。本文总结了影响药物处置的性别差异，并对适用于男性和女性的临床药理学进行了总体比较。