Agarwal Neha, Gainder Shalini, Chopra Seema, Rohilla Minakshi, Prasad Grv, Jain Vanita
Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research, Chandigarh, IND.
Obstetrics and Gynecology, Maulana Azad Medical College, New Delhi, IND.
Cureus. 2021 Jun 23;13(6):e15881. doi: 10.7759/cureus.15881. eCollection 2021 Jun.
This study aimed to highlight the clinical features, diagnosis, and different modalities of the treatment of cesarean scar pregnancy (CSP).
This study was done in the tertiary referral hospital of India for one year. A total of 11 cases were enrolled prospectively. In each case, the diagnostic ultrasonography and measurement of baseline beta-human chorionic gonadotropin (β-HCG) levels were done. The treatment was given based on the hemodynamic status of the patient and desire for future fertility. Various treatment modalities used were medical, surgical, or interventional digital subtraction angiography to control hemorrhage. Also, in some cases, ultrasound-guided methotrexate was injected into the scar ectopic. Medically treated cases were followed up until their β-HCG levels became normal.
Out of 11 patients, six had a history of two cesarean sections in the past, four patients had a history of one cesarean section and one patient with a previous three low segments cesarean section (LSCS). Seven out of 11 patients underwent medical management with either methotrexate with potassium chloride (KCl) or methotrexate alone. The success of the medical management was monitored by serial β- HCG values. The mean time for the resolution of these 10 patients was 86.7 ± 53.6 days. Three patients underwent emergency uterine artery embolization due to uncontrolled bleeding and one patient required laparotomy.
CSP is a life-threatening condition that can be diagnosed with the help of transvaginal ultrasonography. The treatment, however, depends on the hemodynamic status of the patient and desire for future fertility. Well-defined diagnostic criteria coupled with structured management and follow-up protocol can help in treating this challenging form of ectopic pregnancy.
本研究旨在突出剖宫产瘢痕妊娠(CSP)的临床特征、诊断及不同治疗方式。
本研究在印度一家三级转诊医院进行了一年。前瞻性纳入了11例患者。对每例患者均进行了诊断性超声检查及基础β-人绒毛膜促性腺激素(β-HCG)水平测定。根据患者的血流动力学状态及对未来生育的意愿给予治疗。所采用的各种治疗方式包括药物治疗、手术治疗或介入性数字减影血管造影以控制出血。此外,在某些病例中,在超声引导下将甲氨蝶呤注入瘢痕部位的异位妊娠处。对接受药物治疗的病例进行随访直至其β-HCG水平恢复正常。
11例患者中,6例既往有两次剖宫产史,4例有一次剖宫产史,1例既往有三次低位剖宫产史。11例患者中有7例接受了甲氨蝶呤联合氯化钾(KCl)或单用甲氨蝶呤的药物治疗。通过连续的β-HCG值监测药物治疗的效果。这10例患者β-HCG水平恢复正常的平均时间为86.7±53.6天。3例患者因出血无法控制接受了急诊子宫动脉栓塞术,1例患者需要进行剖腹手术。
CSP是一种危及生命的疾病,可借助经阴道超声进行诊断。然而,治疗取决于患者的血流动力学状态及对未来生育的意愿。明确的诊断标准以及结构化的管理和随访方案有助于治疗这种具有挑战性的异位妊娠形式。