Aydin Mehmet Dumlu, Aydin Aybike, Caglar Ozgur, Aydin Muhammed Enes, Karadeniz Erdem, Nalci Kemal Alp, Demirtas Rabia
Department of Neurosurgery, Medical Faculty of Ataturk University, Erzurum, Turkey.
Medical Faculty of Cerrapasa, Istanbul University, Istanbul, Turkey.
Bioimpacts. 2021;11(3):181-185. doi: 10.34172/bi.2021.26. Epub 2020 Jul 28.
There have been thousands of neurochemical mechanism about blood glucose level regulation, but intrapancreatic taste buds and their roles in blood glucose level has not been described. We aimed to investigate if there are taste buds cored neural networks in the pancreas, and there is any relationship between blood glucose levels. This examination was done on 32 chosen rats with their glucose levels. Animals are divided into owned blood glucose levels. If mean glucose levels were equal to 105 ± 10 mg/dL accepted as euglycemic (G-I; n = 14), 142 ± 18 mg/dL values accepted as hyperglycemic (G-II; n = 9) and 89 ± 9 mg/dL accepted as hypoglycemic (G-III; n = 9). After the experiment, animals were sacrificed under general anesthesia. Their pancreatic tissues were examined histological methods and numbers of newly described taste bud networks analyzed by Stereological methods. Results compared with Mann-Whitney U test < 0.005 considered as significant. The mean normal blood glucose level (mg/dL) and taste bud network densities of per cm were: 105 ± 10 mg/dL; 156±21 in G-I; 142 ± 18 mg/dL and 95 ± 14 in G-II and 89 ± 9 mg/dL and 232 ± 34 in G-III. values as follows: < 0.001 of G-II/G-I; < 0.005 of G-III/G-I and < 0.0001 of G-III/G-II. We detected periarterial located taste buds like cell clusters and peripherally located ganglia connected with Langerhans cells via thin nerve fibers. There was an inverse relationship between the number of taste buds networks and blood glucose level. Newly described intrapancreatic taste buds may have an important role in the regulation of blood glucose level.
关于血糖水平调节存在数千种神经化学机制，但胰腺内的味蕾及其在血糖水平中的作用尚未得到描述。我们旨在研究胰腺中是否存在以味蕾为核心的神经网络，以及其与血糖水平之间是否存在任何关系。本检查针对32只选定的大鼠及其血糖水平进行。动物根据自身血糖水平进行分组。如果平均血糖水平等于105±10mg/dL，则被视为血糖正常（G-I组；n = 14），142±18mg/dL的值被视为高血糖（G-II组；n = 9），89±9mg/dL被视为低血糖（G-III组；n = 9）。实验结束后，动物在全身麻醉下处死。对其胰腺组织进行组织学检查，并通过体视学方法分析新描述的味蕾网络数量。结果采用曼-惠特尼U检验进行比较，P<0.005被认为具有显著性。每厘米的平均正常血糖水平（mg/dL）和味蕾网络密度如下：G-I组为105±10mg/dL；156±21；G-II组为142±18mg/dL和95±14；G-III组为89±9mg/dL和232±34。G-II/G-I组的值如下：P<0.001；G-III/G-I组P<0.005；G-III/G-II组P<0.0001。我们检测到动脉周围存在类似细胞簇的味蕾以及通过细神经纤维与朗格汉斯细胞相连的外周神经节。味蕾网络数量与血糖水平之间存在负相关关系。新描述的胰腺内味蕾可能在血糖水平调节中发挥重要作用。
