McGuire T C
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
Vet Immunol Immunopathol. 1987 Dec;17(1-4):465-70. doi: 10.1016/0165-2427(87)90162-0.
Evidence is reviewed which indicates that CAEV persists in infected goats with variable and restricted expression. Immunosuppression prevents the lesions caused by CAEV. Arthritis is enhanced in CAEV-challenged goats that have been immunized with inactivated CAEV or are persistently infected with CAEV. A large part of the synovial fluid immunoglobulin is antibody against virion surface glycoproteins. These observations support the hypothesis that the immune response to viral antigens is a major determinant of CAEV arthritis.
