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循环白细胞介素-17 水平与系统性红斑狼疮患者的疾病活动呈正相关:系统评价和荟萃分析。

Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis.

机构信息

Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Faculty of Nursing, Chiang Mai University, Chiangmai, Thailand.

出版信息

Biomed Res Int. 2021 Jul 21;2021:9952463. doi: 10.1155/2021/9952463. eCollection 2021.

Abstract

Previous studies on the relationship between the circulating level of interleukin-17 (IL-17) and disease activity in systemic lupus erythematosus (SLE) were contradictory. This study is aimed at quantitatively assessing the correlation between the circulating IL-17 level and disease activity in SLE patients. A systematic search for related literature was conducted via PubMed, Web of Science, EMBASE, and Cochrane Library (up to January 26, 2021). The relationship between circulating IL-17 levels and SLE activity was evaluated using Fisher's value, which was then converted to . The standardized mean difference (SMD) and its 95% confidence interval (CI) were used to describe the difference between the circulating IL-17 level in patients with active and inactive SLE. STATA 16.0 was used to perform statistical analysis. Random-effects model was performed to synthesize data. Twenty-six studies involving 1,560 SLE patients were included in this review. The pooled value was 0.38 (95% CI: 0.25-0.50; = 83.8%, < 0.001) between the SLE activity and circulating level of IL-17. Patients with active SLE had higher level of circulating IL-17 than that of inactive (pooled SMD = 0.95, 95% CI: 0.38-1.53; = 90.5%, < 0.001). The subgroup analysis suggested that the region and detection method of circulating IL-17 might not be a source of heterogeneity. No significant publication bias was found. In summary, circulating IL-17 level has a low positive relationship with SLE activity. It is necessary to carefully consider the use of circulating IL-17 as a biomarker of the disease activity in SLE patients. The relationship between the circulating level of IL-17 and SLE activity should be further confirmed in randomized controlled studies.

摘要

先前关于白细胞介素-17(IL-17)循环水平与系统性红斑狼疮(SLE)疾病活动之间关系的研究结果存在矛盾。本研究旨在定量评估 SLE 患者循环 IL-17 水平与疾病活动之间的相关性。通过 PubMed、Web of Science、EMBASE 和 Cochrane Library 对相关文献进行系统检索(截至 2021 年 1 月 26 日)。使用 Fisher's 值评估循环 IL-17 水平与 SLE 活动之间的关系,然后将其转换为 。采用标准化均数差(SMD)及其 95%置信区间(CI)描述活动期和非活动期 SLE 患者循环 IL-17 水平的差异。采用 STATA 16.0 进行统计分析。采用随机效应模型进行数据合成。本综述共纳入 26 项研究,包含 1560 例 SLE 患者。SLE 活动与循环 IL-17 水平之间的合并 值为 0.38(95%CI:0.25-0.50; = 83.8%, < 0.001)。活动期 SLE 患者的循环 IL-17 水平高于非活动期(合并 SMD = 0.95,95%CI:0.38-1.53; = 90.5%, < 0.001)。亚组分析提示,循环 IL-17 的检测区域和方法可能不是异质性的来源。未发现明显的发表偏倚。综上所述,循环 IL-17 水平与 SLE 活动呈低度正相关。需要谨慎考虑将循环 IL-17 作为 SLE 患者疾病活动的生物标志物。IL-17 循环水平与 SLE 活动之间的关系需要在随机对照研究中进一步证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29bd/8318742/75c55f054e82/BMRI2021-9952463.001.jpg

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