Elemam Noha M, Talaat Iman M, El Meligy Omar A
Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Research Institute of Medical & Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Front Immunol. 2025 Jul 28;16:1585280. doi: 10.3389/fimmu.2025.1585280. eCollection 2025.
Systemic Lupus Erythematosus (SLE) is a multifaceted autoimmune disorder characterized by widespread inflammation and immune dysregulation, impacting various organ systems and generating autoantibodies. Oral lesions are a common and distressing manifestation of SLE, significantly affecting patients' quality of life. Cytokines, key mediators of immune responses, play a crucial role in the pathogenesis of both systemic and oral manifestations of SLE. This review sheds the light on current research on the involvement of various cytokines, including interleukins different interferon types, and growth factors in SLE. The intricate interplay between pro-inflammatory and anti-inflammatory cytokines contributes to the disease's initiation, progression, and diverse clinical presentations. Elevated levels of pro-inflammatory cytokines exacerbate inflammation, promote apoptosis, and drive autoantibody production. Understanding the specific roles of these cytokines offers potential therapeutic targets for managing SLE and improving patient outcomes.
系统性红斑狼疮（SLE）是一种多方面的自身免疫性疾病，其特征是广泛的炎症和免疫失调，影响多个器官系统并产生自身抗体。口腔病变是SLE常见且令人苦恼的表现，严重影响患者的生活质量。细胞因子作为免疫反应的关键介质，在SLE的全身和口腔表现的发病机制中起着至关重要的作用。本综述阐明了当前关于各种细胞因子（包括不同类型的白细胞介素、干扰素和生长因子）参与SLE的研究。促炎细胞因子和抗炎细胞因子之间复杂的相互作用导致了该疾病的发生、发展和多样的临床表现。促炎细胞因子水平升高会加剧炎症、促进细胞凋亡并驱动自身抗体的产生。了解这些细胞因子的具体作用为管理SLE和改善患者预后提供了潜在的治疗靶点。
