Barinskiĭ I F, Gribencha S V, Nesterchuk S L, Zhdanov V M
Vopr Virusol. 1987 Sep-Oct;32(5):561-5.
The effect of some Soviet chemical drugs (ribamydil, sodium phosphonoformate, acycloguanosine) as well as reaferon (genetic engineering alpha-interferon) and interferon inducers (lafarine, ridastine, rifastine, ENKAD) on HIV retrovirus reproduction was studied in cultures of continuous lymphoid cells H9 and a line of H9/IIIB cells persistently infected with HIV virus. The presence of viral antigen in the cells was determined by quantitative indirect immunofluorescence assays using a working dilution of 1:20 of a serum from an AIDS patient as the immune serum. The above studies showed that 3 drugs: ribamydil (50 micrograms/ml), phosphonoformate (120 micrograms/ml) and recombinant interferon (1000 IU/ml) were capable of statistically significant inhibition of retrovirus replication in continuous cultures of T-lymphocytes.
研究了一些苏联化学药物（利巴米迪尔、膦甲酸钠、阿昔洛韦）以及重组干扰素（基因工程α干扰素）和干扰素诱导剂（拉法林、利达司汀、利法司汀、恩卡德）对HIV逆转录病毒在连续淋巴细胞H9培养物以及持续感染HIV病毒的H9/IIIB细胞系中复制的影响。使用来自一名艾滋病患者血清1:20的工作稀释液作为免疫血清，通过定量间接免疫荧光测定法确定细胞中病毒抗原的存在。上述研究表明，三种药物：利巴米迪尔（50微克/毫升）、膦甲酸钠（120微克/毫升）和重组干扰素（1000国际单位/毫升）能够在T淋巴细胞连续培养物中对逆转录病毒复制产生具有统计学意义的抑制作用。
