Nosik D N, Korneeva M N, Korsun N S, Maĭorova S N, Parshina O V
Vopr Virusol. 1988 Jan-Feb;33(1):34-7.
Trials of clinically advantageous national inducers, thymus hormones, as well as human recombinant alpha 2-interferon were carried out in cultures of continuous lymphoblastoid cells H9/IIIB infected with HIV virus. The virus-inhibiting effect for HIV was observed with interferon in doses of 10-100 IU/ml. At a concentration of interferon of 1000 IU/ml, virus replication was inhibited completely, the interferon doses used exerting no marked toxic or antiproliferative effect on the cells. Human interferon inducers, poly(G).poly(C), PXL-6, dsRNA in concentrations of 50-100 micrograms/ml inhibited virus reproduction significantly. The highest antiviral effect was achieved with yeast dsRNA. The preparations of immunomodulators, thymarin, the 5th and 7th fractions of thymosin, noticeably stimulated proliferation of infected T-lymphocytes, reducing the relative number of cells carrying the virus-specific antigen. Combined use of preparations with different mechanisms of the antiviral effect may be advantageous in prevention and treatment of AIDS.
在感染了HIV病毒的连续淋巴母细胞系H9/IIIB培养物中，对具有临床优势的天然诱导剂、胸腺激素以及人重组α2干扰素进行了试验。在10 - 100 IU/ml剂量的干扰素作用下，观察到了对HIV的病毒抑制效果。当干扰素浓度为1000 IU/ml时，病毒复制被完全抑制，所用的干扰素剂量对细胞没有明显的毒性或抗增殖作用。浓度为50 - 100微克/毫升的人干扰素诱导剂聚（G）·聚（C）、PXL - 6、双链RNA显著抑制病毒繁殖。酵母双链RNA具有最高的抗病毒效果。免疫调节剂胸腺素、胸腺肽的第5和第7组分的制剂明显刺激了受感染T淋巴细胞的增殖，减少了携带病毒特异性抗原的细胞的相对数量。联合使用具有不同抗病毒作用机制的制剂可能对艾滋病的预防和治疗有益。
