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阴茎癌患者中实施动态前哨淋巴结活检和根治性腹股沟淋巴结清扫术的阴茎癌外科医生的实践模式:一项欧洲泌尿生殖系统肿瘤学会(eUROGEN)调查

Practice Patterns Among Penile Cancer Surgeons Performing Dynamic Sentinel Lymph Node Biopsy and Radical Inguinal Lymph Node Dissection in Men with Penile Cancer: A eUROGEN Survey.

作者信息

Fankhauser Christian D, Ayres Benjamin E, Issa Allaudin, Albersen Maarten, Watkin Nick, Muneer Asif, Sangar Vijay, Parnham Arie

机构信息

Department of Urology, The Christie NHS Foundation Trusts, Manchester, UK.

Department of Urology, St George's Hospital, London, UK.

出版信息

Eur Urol Open Sci. 2021 Jan 7;24:39-42. doi: 10.1016/j.euros.2020.12.009. eCollection 2021 Feb.

Abstract

UNLABELLED

Dynamic sentinel lymph node biopsy (DSNB) and radical inguinal lymph node dissection (ILND) are important in the management of penile cancer patients, but high-level evidence for preoperative, perioperative, and postoperative management remains scarce. According to an online survey of 35 surgeons from ten European countries, 57% perform >10 ILND procedures per year and 86% offer DSNB. Furthermore, management differs substantially for dye injection site, use of lymphoscintigraphy, preferred incision sites, techniques for lymphatic control, duration of empiric antibiotic therapy, perioperative thromboprophylaxis, time points for drain removal, and definition of the ILND dissection floor. Consensus was observed for the use of perioperative antibiotics (although not duration and type) and the borders for ILND template definitions. We conclude that there is significant variation in patient management among eUROGEN penile cancer surgeons. This heterogeneity may confound multicentre studies; therefore, a consensus to standardise inguinal node management in penile cancer across European penile cancer centres is warranted.

PATIENT SUMMARY

Our survey reveals that preferences and surgical techniques for inguinal lymph node sampling and removal varies significantly between European penile cancer surgeons. Consensus is needed to standardise the management approach for penile cancer.

摘要

未标注

动态前哨淋巴结活检(DSNB)和根治性腹股沟淋巴结清扫术(ILND)在阴茎癌患者的治疗中很重要,但术前、围手术期和术后管理的高级别证据仍然匮乏。根据对来自十个欧洲国家的35名外科医生的在线调查,57%的医生每年进行超过10例ILND手术,86%的医生提供DSNB。此外,在染料注射部位、淋巴闪烁造影的使用、首选切口部位、淋巴控制技术、经验性抗生素治疗持续时间、围手术期血栓预防、引流管拔除时间点以及ILND清扫范围的定义等方面,管理差异很大。在围手术期抗生素的使用(尽管不是持续时间和类型)以及ILND模板定义的边界方面达成了共识。我们得出结论,欧洲泌尿生殖系统阴茎癌外科医生在患者管理方面存在显著差异。这种异质性可能会混淆多中心研究;因此,有必要在欧洲各阴茎癌中心就阴茎癌腹股沟淋巴结管理进行标准化达成共识。

患者总结

我们的调查显示,欧洲阴茎癌外科医生在腹股沟淋巴结取样和切除的偏好及手术技术方面存在显著差异。需要达成共识以规范阴茎癌的管理方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d8/8317807/927e4c358cee/gr1.jpg

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