Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Kingdom of Saudi Arabia.
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4757-4761. doi: 10.26355/eurrev_202107_26387.
Metformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus. In addition to its ability to lower glucose levels, it has recently been reported to be potentially useful for the treatment of other conditions because of its anticancer activity, cardiovascular protective effect, neuroprotective effect, and efficacy in the treatment of polycystic ovary syndrome. However, long-term use of metformin may lead to side-effects such as memory impairment. Here, we critically review the effect of metformin on memory impairment and the potential molecular mechanisms of memory dysfunction to provide a reference for researchers and a better understanding of the side-effects of metformin.
二甲双胍是治疗 2 型糖尿病最常用的药物。除了降低血糖水平的能力外，最近有报道称，由于其抗癌活性、心血管保护作用、神经保护作用以及在多囊卵巢综合征治疗中的疗效，它可能对其他疾病的治疗也有帮助。然而，长期使用二甲双胍可能会导致记忆障碍等副作用。在这里，我们批判性地回顾了二甲双胍对记忆障碍的影响以及记忆功能障碍的潜在分子机制，为研究人员提供参考，并更好地了解二甲双胍的副作用。
