妊娠糖尿病与巨大儿之间新的表观遗传学联系。
Novel epigenetic link between gestational diabetes mellitus and macrosomia.
机构信息
Center for Global Oncology, Institute for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Tianjin Women's & Children's Health Center, Tianjin, China.
出版信息
Epigenomics. 2021 Aug;13(15):1221-1230. doi: 10.2217/epi-2021-0096. Epub 2021 Aug 2.
Abstract
Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candidate genes , , , , , , and . A total of 1145 children (572 GDM cases and 573 controls) from the Tianjin GDM study, including 177 with macrosomia, had blood DNA collection at median age 5.9 (range: 3.1-10.0). We used logistic regression to screen for associations with GDM and model macrosomia on 37 CpGs, and performed mediation analysis. One CpG was associated with macrosomia at false discovery rate (FDR) <0.05 (cg14428359 in ); two (cg19466922 in and cg26263166 in ) were associated at p < 0.05 but mediated 26 and 13%, respectively. and were previously identified for potential involvement in fetal growth and development (Trial Registration number: NCT01554358 [ClinicalTrials.gov]).
摘要
检查母体妊娠糖尿病（GDM）、巨大儿和候选基因 、 、 、 、 、 的 DNA 甲基化。共有 1145 名儿童（572 例 GDM 病例和 573 例对照）来自天津 GDM 研究，其中 177 例为巨大儿，在中位数年龄 5.9 岁（范围：3.1-10.0）时采集血 DNA。我们使用逻辑回归筛选与 GDM 的关联，并对 37 个 CpG 进行模型分析，进行中介分析。一个 CpG 在 FDR <0.05 时与巨大儿相关（ 中的 cg14428359）; 两个 CpG 在 p<0.05 时与巨大儿相关，但分别介导了 26%和 13%（ 和 中的 cg19466922 和 cg26263166）。 、 、 、 、 、 和 先前被鉴定为可能参与胎儿生长发育（试验注册号：NCT01554358 [ClinicalTrials.gov]）。
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