School of Physical Sciences, 12652University of Science and Technology of China, Hefei, Anhui, China.
90618University of Florida Health Proton Therapy Institute, Jacksonville, FL, USA.
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211033076. doi: 10.1177/15330338211033076.
To commission MCsquare (a multi-cores CPU-based dose calculation engine) for pencil beam scanning (PBS) proton therapy, integrate it into RayStation treatment plan system (TPS) to create a dedicated platform for fast independent dose verification.
A MCsquare-based independent dose verification platform (MC2InRS) was developed to realize automatic dose re-calculation for clinical use, including data preparation, dose calculation, 2D/3D gamma analysis. MCsquare was commissioned based on in-air lateral dose profiles, integrated depth dose, and the absolute dose of different beam energies for ProteusONE. MC2InRS was validated with measurement data using various targets and depths in a water phantom. This study also investigated 15 clinical cases to demonstrate the feasibility and effectiveness of MC2InRS platform in clinic practice.
Between simulation and measurement, the distal range differences at 80% (R80) and 20% (R20) dose levels for each energy were below 0.05 mm, and 0.1 mm, respectively, and the absolute dose differences were below 0.5%. 29 out of 36 QA planes reached a 100% gamma passing rate (GPR) for 2%/2mm criteria, and a minimum of 98.3% gamma was obtained in water phantom between simulation and measurement. For the 15 clinical cases investigated, the average 2D GPR (2%/2mm) was 95.4%, 99.3% for MCsquare vs. measurement, MCsquare vs. TPS, respectively. The average 3D GPR (2%/2mm) was 98.9%, 95.3% for MCsquare vs. TPS in water, and computed tomography (CT), respectively.
MC2InRS, a fast, independent dose verification platform, has been developed to perform dose verification with high accuracy and efficiency for Pencil Bream Scanning (PBS). Its potential to be applied in routine clinical practice has also been discussed.
委托基于多核 CPU 的剂量计算引擎（MCsquare）用于铅笔束扫描（PBS）质子治疗，将其集成到 RayStation 治疗计划系统（TPS）中，为快速独立剂量验证创建专用平台。
开发了基于 MCsquare 的独立剂量验证平台（MC2InRS），以实现临床使用的自动剂量重新计算，包括数据准备、剂量计算、2D/3D 伽马分析。根据空气侧向剂量分布、集成深度剂量以及 ProteusONE 不同束能的绝对剂量对 MCsquare 进行了委托。使用水模中的各种靶标和深度的测量数据对 MC2InRS 进行了验证。本研究还对 15 个临床病例进行了调查，以证明 MC2InRS 平台在临床实践中的可行性和有效性。
在模拟和测量之间，每个能量的 80%（R80）和 20%（R20）剂量水平的远端范围差异均低于 0.05 毫米和 0.1 毫米，绝对剂量差异低于 0.5%。36 个 QA 平面中有 29 个达到了 2%/2mm 标准的 100%伽马通过率（GPR），水模中模拟和测量之间的最小伽马值为 98.3%。对于调查的 15 个临床病例，MCsquare 与测量值、MCsquare 与 TPS 的平均 2D GPR（2%/2mm）分别为 95.4%和 99.3%。水模和计算机断层扫描（CT）中 MCsquare 与 TPS 的平均 3D GPR（2%/2mm）分别为 98.9%和 95.3%。
开发了快速、独立的剂量验证平台 MC2InRS，可实现高精度、高效率的铅笔束扫描（PBS）剂量验证。还讨论了其在常规临床实践中的应用潜力。
