Institute for Urology and Human Reproductive Health, Sechenov University, Moscow, Russia.
Urologia. 2022 May;89(2):179-184. doi: 10.1177/03915603211036427. Epub 2021 Aug 2.
The purpose of the study is the development and evaluation of the informativeness of the author's 3D nephrometric score application to predict the probability of intraoperative and postoperative complications in kidney operations.
The study includes 264 patients who underwent surgical treatment of renal tumors, before that CT and 3D modeling were carried out. All patients underwent an analysis of the surgical intervention complexity on the C-index, PADUA, R.E.N.A.L., and developed 3D nephrometric score. To determine the set of variables that allow to classify patients, the method of discriminant analysis was used to predict the nature, volume of blood loss, duration of ischemia, and the number of complications. The sensitivity and specificity of the predictors were estimated with the help of ROC analysis.
Indicators have been established to classify patients according to the probability of complications, the amount of blood loss and the duration of ischemia during surgery for kidney cancer. We have created linear models that predict the development of bleeding during surgery, the volume of blood loss of more than 200 ml and the duration of ischemia more than 20 min, as well as the likelihood of complications using discriminant functions. The proposed author's nephrometric score exceeds the capabilities of C-index, PADUA, R.E.N.A.L in many ways in blood loss and time of ischemia predicting, which allows us to recommend it for the assessment of resectability in kidney operations.
本研究旨在开发和评估作者的 3D 肾计量评分的信息量,以预测肾脏手术中手术和术后并发症的概率。
本研究纳入 264 例接受肾脏肿瘤手术治疗的患者,术前进行 CT 和 3D 建模。所有患者均进行 C 指数、PADUA、R.E.N.A.L. 和作者开发的 3D 肾计量评分分析手术干预复杂性。为了确定可对患者进行分类的变量集,使用判别分析方法预测出血、失血量、缺血持续时间和并发症的性质和数量。借助 ROC 分析评估预测因子的灵敏度和特异性。
已经建立了根据肾细胞癌患者发生并发症、术中出血量和缺血持续时间的概率进行分类的指标。我们创建了线性模型,用于预测手术中出血、出血量超过 200ml 和缺血持续时间超过 20min 的情况,以及使用判别函数预测并发症发生的可能性。与 C 指数、PADUA 和 R.E.N.A.L. 相比,提出的作者的肾计量评分在预测失血量和缺血时间方面具有许多优势,这使我们能够推荐其用于评估肾脏手术的可切除性。