Dept. Internal Medicine 2, General Hospital Mistelbach-Gänserndorf, Liechtensteinstraße 67, 2130, Mistelbach, Austria.
Dept. Nuclear Medicine, Wilhelminenspital, Vienna, Austria.
Wien Med Wochenschr. 2022 Sep;172(11-12):274-279. doi: 10.1007/s10354-021-00862-6. Epub 2021 Aug 2.
In January 2019, a 30-year-old woman admitted to our inpatient department presented with undulating fever, pain in several joints, and significantly elevated liver enzymes and lactate dehydrogenase. After extended examination, infection with Brucella melitensis with liver, musculoskeletal, and pulmonary involvement was diagnosed and treated. Diagnosis was based on clinical examination, laboratory findings including seroconversion as a proof of immune response, magnetic resonance imaging, three-phase bone scintigraphy, and F‑18 FDG-PET (F-18 Flourdeoxyglucose positron emission tomography) illustrating the bone involvement and its normalization upon treatment. After treatment the patient showed a remarkable improvement of clinical symptoms within a short period. The patient remained symptom free and polymerase chain reaction (PCR) testing for brucellosis was negative, even at the follow-up examination 12 months after the end of the antibiotic therapy. The family members were also examined due to the similar travel history, and by this, brucellosis was also diagnosed in her husband but not in her children.
2019 年 1 月，一位 30 岁女性因不规则发热、多关节疼痛及肝酶和乳酸脱氢酶显著升高而入住我院。经过详细检查，诊断为感染布鲁氏菌病，累及肝脏、肌肉骨骼和肺部，并进行了相应治疗。诊断基于临床检查、实验室检查（包括血清学转换以证明免疫反应）、磁共振成像、三相骨闪烁扫描和 F-18 FDG-PET（氟代脱氧葡萄糖正电子发射断层扫描），这些检查显示了骨骼受累情况及其在治疗后的正常化。治疗后，患者在短时间内临床症状显著改善。患者无任何症状，且聚合酶链反应（PCR）检测布鲁氏菌病结果为阴性，即使在抗生素治疗结束后 12 个月的随访检查时也是如此。由于有类似的旅行史，对患者家属也进行了检查，发现其丈夫也患有布鲁氏菌病，但她的孩子没有。
