Laboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
Embrapa Amapá, Macapá, Brazil.
J Fish Dis. 2021 Nov;44(11):1819-1829. doi: 10.1111/jfd.13501. Epub 2021 Aug 2.
Parasite infections in fish require constant surveillance and strategies for efficient treatments which guarantee the fish health, their sale value and the non-propagation of pathogens in new environments. Fish treatments based on nanotechnology become of increasing interest since nanoparticles have been shown as efficient materials for optimizing administration of bioactives. In this study a chitosan derivative, alginate and praziquantel conjugated nanobioparticle of effective action for oral treatment of digenetic trematodes in highly infected Corydoras schwartzi was evaluated in terms of histological and hematological safety. The inherent absence of alterations in intestinal tissue and the reversible blood cells counting during a period up to 35 days showed the safety of the drug delivery nanobioparticles, which thus represent a promising strategy for effective applications in pathogens treatments by oral administration.
鱼类寄生虫感染需要持续监测和有效的治疗策略，以保证鱼类的健康、销售价值以及病原体在新环境中的不传播。基于纳米技术的鱼类治疗方法越来越受到关注，因为纳米颗粒已被证明是优化生物活性物质给药的有效材料。在这项研究中，壳聚糖衍生物、海藻酸钠和吡喹酮共轭纳米生物粒子对高度感染的黑裙鱼消化道吸虫的口服治疗效果进行了评估，考察了其在组织学和血液学方面的安全性。在长达 35 天的时间内，肠道组织没有出现固有变化，血细胞计数也可以恢复正常，这表明药物输送纳米生物粒子是安全的，因此为通过口服途径进行有效病原体治疗提供了一种很有前途的策略。
