Williams Rissa E, Ernst Ingo, Chambers Clinton B, Whittington Ian D
School of Earth and Environmental Sciences, Darling Building, DP418, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Dis Aquat Organ. 2007 Oct 15;77(3):199-205. doi: 10.3354/dao01824.
We investigated the efficacy of praziquantel (PZQ) administered orally to yellowtail kingfish (Seriola lalandi in sea-cage aquaculture in South Australia) against the monogeneans Zeuxapta seriolae and Benedenia seriolae infesting gills and skin, respectively. PZQ was administered to fish by surface-coating feed pellets (Trial 1) or by direct intubation of the stomach (Trial 2). In both trials 4 daily doses were administered: 50 and 75 mg kg(-1) body weight (BW) d(-1) for 6 d, and 100 and 150 mg kg(-1) BW d(-1) for 3 d. Mean parasite intensity was compared between medicated fish and unmedicated control fish. In Trial 1, fish fed lower daily doses of PZQ for 6 d (50 and 75 mg kg(-1) BW d(-1)) had fewer Z. seriolae and B. seriolae than fish fed higher daily doses for 3 d (100 and 150 mg kg(-1) BW d(-1)). Fish rejected feed pellets surface-coated with PZQ, suggesting PZQ affected palatability of feed, and may explain differences in efficacy between treatments. In Trial 2, where PZQ was administered by intubation, there were fewer Z. seriolae and B. seriolae in medicated fish than control fish. Intubated PZQ was also effective against newly recruited Z. seriolae and B. seriolae. PZQ could be developed as a useful treatment for Z. seriolae and B. seriolae parasitising S. lalandi in sea-cage aquaculture if suspected palatability problems are resolved.
我们研究了口服吡喹酮（PZQ）对南澳大利亚海水网箱养殖的黄尾鰤（Seriola lalandi）的疗效，该药物分别用于对抗寄生在鳃和皮肤的单殖吸虫Zeuxapta seriolae和Benedenia seriolae。通过在饲料颗粒表面包衣（试验1）或直接插管入胃（试验2）的方式给鱼投喂PZQ。在两个试验中，均每日给药4次：体重50和75毫克/千克（BW）/天，持续6天；以及体重100和150毫克/千克BW/天，持续3天。比较用药鱼和未用药对照鱼之间的平均寄生虫感染强度。在试验1中，每日投喂较低剂量PZQ持续6天（50和75毫克/千克BW/天）的鱼，其体内的Zeuxapta seriolae和Benedenia seriolae数量少于每日投喂较高剂量持续3天（100和150毫克/千克BW/天）的鱼。鱼拒绝食用表面包衣有PZQ的饲料颗粒，这表明PZQ影响了饲料的适口性，这可能解释了不同处理之间疗效的差异。在试验2中，通过插管给药PZQ，用药鱼体内的Zeuxapta seriolae和Benedenia seriolae数量少于对照鱼。插管给药的PZQ对新感染的Zeuxapta seriolae和Benedenia seriolae也有效。如果解决了疑似适口性问题，PZQ可开发成为一种有效的治疗方法，用于治疗海水网箱养殖的黄尾鰤体内寄生的Zeuxapta seriolae和Benedenia seriolae。
