Geib R W, Dizik M, Anand R, Lilly F
Terre Haute Center for Medical Education, Indiana Unviersity School of Medicine, Terre Haute 47809.
Virus Res. 1987 Nov;8(4):327-33. doi: 10.1016/0168-1702(87)90005-0.
Friend virus was used to infect and transform Fv-2rr erythroprogenitor cells in vivo. The RB (Fv-2rr) cell line was characteristic of Friend virus-induced cell lines in Fv-2ss mice, i.e., it produced infectious Friend virus and synthesized hemoglogin. The RB (Fv-2rr) cell line expressed the envelope protein of the spleen focus-forming virus (gp52) and a novel, related envelope protein (gp48). The results demonstrate that Fv-2rr erythroprogenitor cells can be infected and transformed in vivo.
用Friend病毒在体内感染并转化Fv-2rr红细胞祖细胞。RB(Fv-2rr)细胞系具有Fv-2ss小鼠中Friend病毒诱导的细胞系的特征,即它产生有传染性的Friend病毒并合成血红蛋白。RB(Fv-2rr)细胞系表达脾集落形成病毒的包膜蛋白(gp52)和一种新的相关包膜蛋白(gp48)。结果表明,Fv-2rr红细胞祖细胞可在体内被感染并转化。