Huang Liqiao, Liu Jie, Bie Caiqun, Liu Helu, Ji Yichun, Chen Dongfeng, Zhu Meiling, Kuang Weihong
Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen 518104, China; The First Affiliated Hospital, Guangzhou TCM University, Guangzhou 510006, China.
Clin Res Hepatol Gastroenterol. 2022 Feb;46(2):101783. doi: 10.1016/j.clinre.2021.101783. Epub 2021 Jul 31.
Acute-on-chronic liver failure (ACLF) has been a hot spot in the field of liver disease research in recent years, with high morbidity, rapid course change and high mortality. Currently, there is the absence of specific treatment in clinical practice. Liver transplantation has the best therapeutic effect, but it is prone to have internal environment disorder and liver cell death after transplantation, which leads to the failure of transplantation.In recent years, with the development of molecular biology, scholars have explored the treatment of ACLF at the molecular level, and more and more molecular signaling pathways related to the treatment of ACLF have been discovered. Modulating the relevant signaling pathways to reduce the mortality of liver cells after transplantation may effectively improve the success rate of transplantation. In this review, we introduce some signaling pathways related to cell death and their research progress in acute-on-chronic liver failure.
慢加急性肝衰竭（ACLF）近年来一直是肝病研究领域的热点，其发病率高、病程变化快且死亡率高。目前，临床实践中缺乏特异性治疗方法。肝移植具有最佳治疗效果，但移植后易出现内环境紊乱和肝细胞死亡，导致移植失败。近年来，随着分子生物学的发展，学者们在分子水平上探索ACLF的治疗方法，发现了越来越多与ACLF治疗相关的分子信号通路。调节相关信号通路以降低移植后肝细胞死亡率可能有效提高移植成功率。在本综述中，我们介绍一些与细胞死亡相关的信号通路及其在慢加急性肝衰竭中的研究进展。
