Wang Yukun, Shi Chunxia, Guo Jin, Zhang Yanqiong, Gong Zuojiong
Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
J Clin Transl Hepatol. 2023 Nov 28;11(6):1413-1424. doi: 10.14218/JCTH.2023.00132. Epub 2023 Jul 24.
Cell death is associated with a variety of liver diseases, and hepatocyte death is a core factor in the occurrence and progression of liver diseases. In recent years, new cell death modes have been identified, and certain biomarkers have been detected in the circulation during various cell death modes that mediate liver injury. In this review, cell death modes associated with liver diseases are summarized, including some cell death modes that have emerged in recent years. We described the mechanisms associated with liver diseases and summarized recent applications of targeting cell death in liver diseases. It provides new ideas for the diagnosis and treatment of liver diseases. In addition, multiple cell death modes can contribute to the same liver disease. Different cell death modes are not isolated, and they interact with each other in liver diseases. Future studies may focus on exploring the regulation between various cell death response pathways in liver diseases.
细胞死亡与多种肝脏疾病相关，肝细胞死亡是肝脏疾病发生和进展的核心因素。近年来，已鉴定出新型细胞死亡模式，并且在介导肝损伤的各种细胞死亡模式期间在循环中检测到某些生物标志物。在本综述中，总结了与肝脏疾病相关的细胞死亡模式，包括近年来出现的一些细胞死亡模式。我们描述了与肝脏疾病相关的机制，并总结了靶向细胞死亡在肝脏疾病中的最新应用。它为肝脏疾病的诊断和治疗提供了新思路。此外，多种细胞死亡模式可导致同一种肝脏疾病。不同的细胞死亡模式并非孤立存在，它们在肝脏疾病中相互作用。未来的研究可能集中于探索肝脏疾病中各种细胞死亡反应途径之间的调控。
