Salem G
Wien Klin Wochenschr Suppl. 1978;82:1-21.
After a short description of the technique of experimental lung homotransplantation, the function of the graft is investigated both from the haemodynamic and respiratory point of view. Perfusion of the transplant was studied in acute and chronic experiments. The haemodynamic rate can be normal even when there are signs of rejection. In the first week there was always a decrease in the perfusion ratio. Lung function tests revealed adequate functional capacity of the graft, capable of sustaining life of the animal, as long as rejection is kept under control. Normal values as obtained with a healthy organ were not achieved, however. Studies in dogs with pathological changes in the contralateral lung showed that the graft is able to tolerate the total cardiac output and to provide adequate respiratory function. In animals with an emphysematous contralateral lung, no ventilation-perfusion imbalance resulted in the homotransplanted organ even when unilateral papain instillation had induced severe emphysematous changes in lung structure of the contralateral organ.
在对实验性肺同种异体移植技术进行简短描述后，从血液动力学和呼吸角度对移植物的功能进行了研究。在急性和慢性实验中对移植物的灌注进行了研究。即使存在排斥反应迹象，血液动力学速率也可能正常。在第一周，灌注率总是会下降。肺功能测试显示移植物具有足够的功能能力，只要排斥反应得到控制，就能维持动物的生命。然而，并未达到健康器官所获得的正常值。对侧肺有病理变化的犬类研究表明，移植物能够耐受全心输出量并提供足够的呼吸功能。在对侧肺为肺气肿的动物中，即使单侧注入木瓜蛋白酶已导致对侧器官肺结构出现严重的肺气肿变化，同种异体移植器官也未出现通气-灌注失衡。
